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Literature summary extracted from

  • Tsuji, K.; Mitsutake, S.; Yokose, U.; Sugiura, M.; Kohama, T.; Igarashi, Y.
    Role of ceramide kinase in peroxisome proliferator-activated receptor beta-induced cell survival of mouse keratinocytes (2008), FEBS J., 275, 3815-3826.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.138 peroxisome proliferator-activated receptor beta upregulation of CERK through activation of peroxisome proliferator-activated receptor beta (PPARbeta) results in decreased intracellular ceramide levels and increased cell survival with less cell death Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.138 ceramide + ATP Mus musculus CerK and C1P are involved in many cell functions, including membrane fusion, phagocytosis and degranulation in mast cells ceramide 1-phosphate + ADP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.138 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.138 keratinocyte mouse keratinocyte cell line SP1 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.138 ceramide + ATP
-
 Mus musculus ceramide 1-phosphate + ADP
-
 ?
2.7.1.138 ceramide + ATP CerK and C1P are involved in many cell functions, including membrane fusion, phagocytosis and degranulation in mast cells Mus musculus ceramide 1-phosphate + ADP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.138 CERK
-
 Mus musculus