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Literature summary extracted from

  • Pan, Y.T.; Carroll, J.D.; Asano, N.; Pastuszak, I.; Edavana, V.K.; Elbein, A.D.
    Trehalose synthase converts glycogen to trehalose (2008), FEBS J., 275, 3408-3420.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.4.99.16 expressed in Escherichia coli Mycolicibacterium smegmatis
5.4.99.16 expressed in Escherichia coli Mycobacterium tuberculosis

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.4.99.16 Ca2+ the MTase activity of TreS is inhibited by 5 mM Ca2+ and other divalent cations Mycobacterium tuberculosis
5.4.99.16 Ca2+ the MTase activity of TreS is inhibited by 5 mM Ca2+ and other divalent cations Mycolicibacterium smegmatis
5.4.99.16 additional information not inhibited by acarbose Mycobacterium tuberculosis
5.4.99.16 additional information not inhibited by acarbose Mycolicibacterium smegmatis
5.4.99.16 validoxylamine strong inhibition Mycobacterium tuberculosis
5.4.99.16 validoxylamine strong inhibition Mycolicibacterium smegmatis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
5.4.99.16 10
-
maltose in 40 mM potassium phosphate buffer (pH 6.8), at 37°C Mycolicibacterium smegmatis
5.4.99.16 90
-
alpha,alpha-trehalose in 40 mM potassium phosphate buffer (pH 6.8), at 37°C Mycolicibacterium smegmatis

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
5.4.99.16 65000
-
6 * 65000, SDS-PAGE Mycolicibacterium smegmatis
5.4.99.16 65000
-
6 * 65000, SDS-PAGE Mycobacterium tuberculosis
5.4.99.16 68000
-
6 * 68000, gel filtration Mycolicibacterium smegmatis
5.4.99.16 68000
-
6 * 68000, gel filtration Mycobacterium tuberculosis
5.4.99.16 390000
-
gel filtration Mycolicibacterium smegmatis
5.4.99.16 390000
-
gel filtration Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
5.4.99.16 Mycobacterium tuberculosis
-
-
-
5.4.99.16 Mycolicibacterium smegmatis
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
5.4.99.16 Ni column chromatography Mycobacterium tuberculosis
5.4.99.16 Ni column chromatography, DEAE-cellulose column chromatography, hydroxyapatite column chromatography, aminohexylagarose column chromatography, phenyl-Sepharose column chromatography, and Sephacryl S-200 gel filtration Mycolicibacterium smegmatis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.4.99.16 maltose
-
Mycolicibacterium smegmatis alpha,alpha-trehalose
-
r
5.4.99.16 maltose
-
Mycobacterium tuberculosis alpha,alpha-trehalose
-
r
5.4.99.16 additional information TreS has also amylase activity by producing trehalose from glycogen or maltoheptaose Mycolicibacterium smegmatis ?
-
?
5.4.99.16 additional information TreS has also amylase activity by producing trehalose from glycogen or maltoheptaose Mycobacterium tuberculosis ?
-
?

Subunits

EC Number Subunits Comment Organism
5.4.99.16 homohexamer 6 * 65000, SDS-PAGE Mycolicibacterium smegmatis
5.4.99.16 homohexamer 6 * 65000, SDS-PAGE Mycobacterium tuberculosis
5.4.99.16 homohexamer 6 * 68000, gel filtration Mycolicibacterium smegmatis
5.4.99.16 homohexamer 6 * 68000, gel filtration Mycobacterium tuberculosis

Synonyms

EC Number Synonyms Comment Organism
5.4.99.16 MTase
-
Mycolicibacterium smegmatis
5.4.99.16 MTase
-
Mycobacterium tuberculosis
5.4.99.16 Trehalose synthase
-
Mycolicibacterium smegmatis
5.4.99.16 Trehalose synthase
-
Mycobacterium tuberculosis
5.4.99.16 TreS
-
Mycolicibacterium smegmatis
5.4.99.16 TreS
-
Mycobacterium tuberculosis

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
5.4.99.16 0.000025
-
validoxylamine in 40 mM potassium phosphate buffer (pH 6.8), at 37°C Mycolicibacterium smegmatis