EC Number | Application | Comment | Organism |
---|---|---|---|
7.1.1.2 | medicine | inhibition of complex I may elicit enhanced formation of reactive oxygen species and contribute thus to neuronal injury | Rattus norvegicus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
7.1.1.2 | DL-homocysteic acid | marked (ca. 64%) decrease of respiratory chain complex I activity in the cerebral cortex of immature rats following seizures induced by bilateral intracerebroventricular infusion of DL-homocysteic acid (600 nanomol/side). Decrease is already evident during the acute phase of seizures (60-90 min after infusion) and persists for at least 20 h after the seizures. Inhibition is selective for complex I since activities of complex II and IV and citrate synthase remain unaffected. Inhibition of complex I activity is not associated with changes in complex I content. Enhanced production of reactive oxygen species by inhibited complex I in mitochondria from DL-homocysteic acid-treated animals. Competitive NMDA receptor antagonist AP7, a selective and potent group II mGluR agonist (2R,4R)-APDC and a highly selective group III mGluR, subtype 8, agonist (S)-3,4-DCPG, significantly reduce the extent of complex I inhibition. The superoxide dismutase mimetic Tempol and a selective peroxynitrite scavenger and decomposition catalyst FeTPPS provide a significant attenuation of complex I inhibition associated with DL-homocysteic acid-induced seizures | Rattus norvegicus | |
7.1.1.2 | rotenone | rotenone-induced increment of H2O2 production is 2fold higher upon DL-homocysteic acid-treatment, thus clearly indicating elevated production of reactive oxygen species at complex I | Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
7.1.1.2 | mitochondrion | - |
Rattus norvegicus | 5739 | - |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
7.1.1.2 | Rattus norvegicus | - |
immature 12-day-old male Wistar albino rats | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
7.1.1.2 | cerebral cortex | - |
Rattus norvegicus | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
7.1.1.2 | 35.91 | - |
ca. 20 h survival after seizures | Rattus norvegicus |
7.1.1.2 | 36.28 | - |
acute phase of seizures | Rattus norvegicus |
7.1.1.2 | 100.6 | - |
controls | Rattus norvegicus |
7.1.1.2 | 102 | - |
controls | Rattus norvegicus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
7.1.1.2 | glutamate | - |
Rattus norvegicus | ? | - |
? | |
7.1.1.2 | malate | - |
Rattus norvegicus | ? | - |
? | |
7.1.1.2 | NADH + decyl-ubiquinone + H+ | - |
Rattus norvegicus | NAD+ + decyl-ubiquinol | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
7.1.1.2 | complex I | - |
Rattus norvegicus |
7.1.1.2 | NADH-ubiquinone oxidoreductase | - |
Rattus norvegicus |