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Literature summary extracted from

  • Barnett, M.; Lin, D.; Akoyev, V.; Willard, L.; Takemoto, D.
    Protein kinase C epsilon activates lens mitochondrial cytochrome c oxidase subunit IV during hypoxia (2008), Exp. Eye Res., 86, 226-234.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
7.1.1.9 additional information protein kinase C epsilon activates under hypoxic conditions. CytCOx activity is increased by 5fold after hypoxia. Under normoxic conditions, in whole lenses, there is only a weak interaction between protein kinase C epsilon and CytCOx Mus musculus

Application

EC Number Application Comment Organism
7.1.1.9 medicine protein kinase C epsilon is activated by hypoxia, which results in the activation of the mitochondrial protein CytCOx, which can protect the lens from mitochondrial damage under naturally hypoxic conditions observed in this tissue Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.1.1.9 mitochondrion
-
 Mus musculus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
7.1.1.9 Mus musculus
-
 B6.129S4-Prkce/tm1/Msg/J mice and Prcke/tm1/Msg-2-3
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.1.1.9 lens
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.1.1.9 ferrocytochrome c + O2 + H+
-
 Mus musculus ferricytochrome c + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.1.1.9 CytCOx
-
 Mus musculus
7.1.1.9 cytochrome c oxidase subunit IV
-
 Mus musculus