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Literature summary extracted from

  • Kleiveland, C.R.; Kassem, M.; Lea, T.
    Human mesenchymal stem cell proliferation is regulated by PGE2 through differential activation of cAMP-dependent protein kinase isoforms (2008), Exp. Cell Res., 314, 1831-1838.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.11 prostaglandin E2 0.05 mM induce activity by elevation of cAMP levels Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.11 H-89 PKA specific inhibitor Homo sapiens
2.7.11.11 additional information not inhibited by wortmannin Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.11 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.11 mesenchymal stem cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.11 ATP + glycogen synthase kinase 3beta phosphorylation of glycogen synthase kinase 3beta is carried out by the PKA type II isoform Homo sapiens ADP + phosphorylated glycogen synthase kinase 3beta
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.11 PKA type I isoform Homo sapiens
2.7.11.11 PKA type II isoform Homo sapiens
2.7.11.11 protein kinase A
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.11 ATP
-
 Homo sapiens
2.7.11.11 cAMP dependent Homo sapiens