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Literature summary extracted from

  • Beale, E.G.
    5-AMP-activated protein kinase signaling in Caenorhabditis elegans (2008), Exp. Biol. Med., 233, 12-20.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.31 additional information AMPK is activated by phosphorylation through upstream kinases and 5'-AMP in response to various nutritional and stress signals Caenorhabditis elegans

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.31 subunit sequence comparisons and phylogenetic trees, overview Caenorhabditis elegans

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.31 ATP + [acetyl-CoA carboxylase] Caenorhabditis elegans inhibition of acetyl-CoA carboxylase ADP + [acetyl-CoA carboxylase] phosphate
-
 ?
2.7.11.31 ATP + [HMG-CoA reductase] Caenorhabditis elegans inhibition of HMG-CoA carboxylase ADP + [HMG-CoA reductase] phosphate
-
 ?
2.7.11.31 additional information Caenorhabditis elegans AMPK promotes ATP production and inhibits ATp consumption acting as a metabolic switch, mechanism, overview. AMPK is activated by phosphorylation through upstream kinases and 5'-AMP in response to various nutritional and stress signals, AMPK signaling pathways, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.31 Caenorhabditis elegans
-
 two alpha, two beta, and five gamma gene orthologues encoding the subunit variants
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.31 phosphoprotein AMPK is activated by phosphorylation through upstream kinases and 5'-AMP in response to various nutritional and stress signals Caenorhabditis elegans

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.31 ATP + [acetyl-CoA carboxylase]
-
 Caenorhabditis elegans ADP + [acetyl-CoA carboxylase] phosphate
-
 ?
2.7.11.31 ATP + [acetyl-CoA carboxylase] inhibition of acetyl-CoA carboxylase Caenorhabditis elegans ADP + [acetyl-CoA carboxylase] phosphate
-
 ?
2.7.11.31 ATP + [HMG-CoA reductase]
-
 Caenorhabditis elegans ADP + [HMG-CoA reductase] phosphate
-
 ?
2.7.11.31 ATP + [HMG-CoA reductase] inhibition of HMG-CoA carboxylase Caenorhabditis elegans ADP + [HMG-CoA reductase] phosphate
-
 ?
2.7.11.31 additional information AMPK promotes ATP production and inhibits ATp consumption acting as a metabolic switch, mechanism, overview. AMPK is activated by phosphorylation through upstream kinases and 5'-AMP in response to various nutritional and stress signals, AMPK signaling pathways, overview Caenorhabditis elegans ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.11.31 trimer alphabetagamma heterotrimer Caenorhabditis elegans

Synonyms

EC Number Synonyms Comment Organism
2.7.11.31 5-AMP-activated protein kinase
-
 Caenorhabditis elegans
2.7.11.31 AMPK
-
 Caenorhabditis elegans

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.31 AMP dependent on, AMPK is activated by phosphorylation through upstream kinases and 5'-AMP in response to various nutritional and stress signals Caenorhabditis elegans