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Literature summary extracted from

  • Bucci, M.; Mirone, V.; Di Lorenzo, A.; Vellecco, V.; Roviezzo, F.; Brancaleone, V.; Ciro, I.; Cirino, G.
    Hydrogen Sulphide Is Involved in Testosterone Vascular Effect (2008), Eur. Urol., 56, 378-383.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.4.1.1 additional information testosterone incubation of rat aorta does not change CSE expression. Testosterone modulates H2S levels by increasing the enzymatic conversion of L-cysteine to H2S Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.4.1.1 Beta-cyano-L-alanine 10 mM inhibits testosterone induced H2S biosynthesis Rattus norvegicus
4.4.1.1 propargylglycine 10 mM inhibits testosterone induced H2S biosynthesis Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
4.4.1.1 Rattus norvegicus
-
 male Wistar rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.4.1.1 aorta
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.4.1.1 L-cysteine + H2O
-
 Rattus norvegicus sulfide + NH3 + pyruvate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.4.1.1 CSE
-
 Rattus norvegicus
4.4.1.1 cystathionine gamma lyase
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
4.4.1.1 pyridoxal 5'-phosphate
-
 Rattus norvegicus