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Literature summary extracted from

  • Giusti, S.; Converso, D.P.; Poderoso, J.J.; Fiszer de Plazas, S.
    Hypoxia induces complex I inhibition and ultrastructural damage by increasing mitochondrial nitric oxide in developing CNS (2008), Eur. J. Neurosci., 27, 123-131.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.1.1.2 rotenone
-
Gallus gallus
7.1.1.2 YLVCGERGFFYTPKA hypoxia causes prolonged inhibition of maximal complex I activity and ultrastructural phenotypes associated with swelling, namely, fading of cristae, intracristal dilations and membrane disruption. Administration of the selective neuronal nitric oxide synthase inhibitor 7-nitroindazole 20 min before hypoxia prevents complex I inhibition in a dose-dependent manner and most ultrastructural damage Gallus gallus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.1.1.2 mitochondrion
-
Gallus gallus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
7.1.1.2 Gallus gallus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.1.1.2 embryo
-
Gallus gallus
-
7.1.1.2 optic lobe
-
Gallus gallus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.1.1.2 NADH + benzoquinone + H+
-
Gallus gallus NAD+ + benzoquinol
-
?

Synonyms

EC Number Synonyms Comment Organism
7.1.1.2 complex I
-
Gallus gallus
7.1.1.2 NADH: ubiquinone oxidoreductase
-
Gallus gallus