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Literature summary extracted from

  • Farhanullah, ; Kang, T.; Yoon, E.J.; Choi, E.C.; Kim, S.; Lee, J.
    2-[2-Substituted-3-(3,4-dichlorobenzylamino)propylamino]-1H-quinolin-4-ones as Staphylococcus aureus methionyl-tRNA synthetase inhibitors (2008), Eur. J. Med. Chem., 44, 239-250.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.1.1.10 2-[2-allyloxy-3-(3,4-dichlorobenzylamino)-propylamino]-1H-quinolin-4-one
-
 Staphylococcus aureus
6.1.1.10 2-[2-amino-3-(3,4-dichlorobenzylamino)-propylamino]-1H-quinolin-4-one tri(trifluoroacetic acid)
-
 Staphylococcus aureus
6.1.1.10 2-[2-benzyloxy-3-(3,4-dichlorobenzylamino)-propylamino]-1H-quinolin-4-one
-
 Staphylococcus aureus
6.1.1.10 2-[3-(3,4-dichlorobenzylamino)-2-dimethylaminopropylamino]-1H-quinolin-4-one
-
 Staphylococcus aureus
6.1.1.10 2-[3-(3,4-dichlorobenzylamino)-2-ethoxypropylamino]-1H-quinolin-4-one
-
 Staphylococcus aureus
6.1.1.10 2-[3-(3,4-dichlorobenzylamino)-2-hydroxymethylpropylamino]-1H-quinolin-4-one
-
 Staphylococcus aureus
6.1.1.10 2-[3-(3,4-dichlorobenzylamino)-2-isopropoxy-propylamino]-1H-quinolin-4-one
-
 Staphylococcus aureus
6.1.1.10 2-[3-(3,4-dichlorobenzylamino)-2-methoxymethylpropylamino]-1H-quinolin-4-one
-
 Staphylococcus aureus
6.1.1.10 2-[3-(3,4-dichlorobenzylamino)-2-propylamino]-1H-quinolin-4-one
-
 Staphylococcus aureus
6.1.1.10 2-[3-[bis-(3,4-dichlorobenzyl)-amino]-2-dimethylamino-propylamino]-1H-quinolin-4-one
-
 Staphylococcus aureus
6.1.1.10 benzoic acid 1-[(3,4-dichlorobenzylamino)-methyl]-2-(4-oxo-1,4-dihydroquinolin-2-ylamino)-ethyl ester
-
 Staphylococcus aureus
6.1.1.10 [1-[(3,4-dichlorobenzylamino)-methyl]-2-(4-oxo-1,4-dihydroquinolin-2-ylamino)ethyl]-carbamic acid tert-butyl ester
-
 Staphylococcus aureus

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.10 Staphylococcus aureus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.1.10 ATP + L-methionine + tRNAMet
-
 Staphylococcus aureus AMP + diphosphate + L-methionyl-tRNAMet
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.1.1.10 methionyl-tRNA synthetase
-
 Staphylococcus aureus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
6.1.1.10 0.0000034
-
-
 Staphylococcus aureus 2-[3-(3,4-dichlorobenzylamino)-2-propylamino]-1H-quinolin-4-one
6.1.1.10 0.0000119
-
-
 Staphylococcus aureus 2-[3-(3,4-dichlorobenzylamino)-2-hydroxymethylpropylamino]-1H-quinolin-4-one
6.1.1.10 0.000015
-
-
 Staphylococcus aureus 2-[3-(3,4-dichlorobenzylamino)-2-methoxymethylpropylamino]-1H-quinolin-4-one
6.1.1.10 0.0000247
-
-
 Staphylococcus aureus 2-[2-benzyloxy-3-(3,4-dichlorobenzylamino)-propylamino]-1H-quinolin-4-one
6.1.1.10 0.0000294
-
-
 Staphylococcus aureus 2-[2-allyloxy-3-(3,4-dichlorobenzylamino)-propylamino]-1H-quinolin-4-one
6.1.1.10 0.0000303
-
-
 Staphylococcus aureus 2-[3-(3,4-dichlorobenzylamino)-2-ethoxypropylamino]-1H-quinolin-4-one
6.1.1.10 0.0000396
-
-
 Staphylococcus aureus 2-[3-(3,4-dichlorobenzylamino)-2-dimethylaminopropylamino]-1H-quinolin-4-one
6.1.1.10 0.0000694
-
-
 Staphylococcus aureus benzoic acid 1-[(3,4-dichlorobenzylamino)-methyl]-2-(4-oxo-1,4-dihydroquinolin-2-ylamino)-ethyl ester
6.1.1.10 0.000091
-
-
 Staphylococcus aureus 2-[3-(3,4-dichlorobenzylamino)-2-isopropoxy-propylamino]-1H-quinolin-4-one
6.1.1.10 0.000102
-
-
 Staphylococcus aureus [1-[(3,4-dichlorobenzylamino)-methyl]-2-(4-oxo-1,4-dihydroquinolin-2-ylamino)ethyl]-carbamic acid tert-butyl ester
6.1.1.10 0.000102
-
-
 Staphylococcus aureus 2-[2-amino-3-(3,4-dichlorobenzylamino)-propylamino]-1H-quinolin-4-one tri(trifluoroacetic acid)
6.1.1.10 0.000131
-
-
 Staphylococcus aureus 2-[3-[bis-(3,4-dichlorobenzyl)-amino]-2-dimethylamino-propylamino]-1H-quinolin-4-one