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Literature summary extracted from

  • Belluti, F.; Piazzi, L.; Bisi, A.; Gobbi, S.; Bartolini, M.; Cavalli, A.; Valenti, P.; Rampa, A.
    Design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors (2008), Eur. J. Med. Chem., 44, 1341-1348.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.7 (3,4-dimethoxyphenyl)-(4-([(2-dimethylaminoethyl)-methylamino]methyl)phenyl)-methanone
-
 Homo sapiens
3.1.1.7 (3,4-dimethoxyphenyl)-(4-([(2-methoxybenzyl)methylamino]methyl)phenyl)-methanone
-
 Homo sapiens
3.1.1.7 (3,4-dimethoxyphenyl)-(4-([methyl-(3-methylbenzyl)amino]methyl)phenyl)methanone
-
 Homo sapiens
3.1.1.7 (3,4-dimethoxyphenyl)-(4-([methyl-(3-nitrobenzyl)amino]methyl)phenyl)methanone
-
 Homo sapiens
3.1.1.7 (3,4-dimethoxyphenyl)-(4-morpholin-4-ylmethylphenyl)methanone
-
 Homo sapiens
3.1.1.7 (3,4-dimethoxyphenyl)-(4-[(methylprop-2-ynylamino)-methyl]phenyl)methanone
-
 Homo sapiens
3.1.1.7 (3,4-dimethoxyphenyl)-{4-[(ethylpropylamino)methyl]phenyl}methanone
-
 Homo sapiens
3.1.1.7 (4-([benzyl-(2-dimethylaminoethyl)amino]methyl)-phenyl)-(3,4-dimethoxyphenyl)methanone
-
 Homo sapiens
3.1.1.7 (4-([benzyl-(2-hydroxyethyl)amino]methyl)phenyl)-(3,4-dimethoxyphenyl)methanone
-
 Homo sapiens
3.1.1.7 (4-[(benzylethylamino)methyl]phenyl)-(3,4-dimethoxyphenyl)methanone
-
 Homo sapiens
3.1.1.7 (4-[(benzylmethylamino)methyl]phenyl)-(3,4-dimethoxyphenyl)methanone
-
 Homo sapiens
3.1.1.7 (4-[(benzylmethylamino)methyl]phenyl)-(3-fluoro-4-methoxyphenyl)methanone
-
 Homo sapiens
3.1.1.7 (4-[(benzylmethylamino)methyl]phenyl)-(4-methoxyphenyl)methanone
-
 Homo sapiens
3.1.1.7 (4-[(benzylmethylamino)methyl]phenyl)naphthalen-2-yl-methanone
-
 Homo sapiens
3.1.1.7 (4-[3-(benzylmethylamino)propenyl]phenyl)-(3,4-dimethoxyphenyl)methanone
-
 Homo sapiens
3.1.1.7 donepezil
-
 Homo sapiens
3.1.1.7 additional information design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors, structure-based drug design, overview Homo sapiens
3.1.1.7 [4-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)phenyl]-(3,4-dimethoxyphenyl)methanone
-
 Homo sapiens
3.1.1.8 (3,4-dimethoxyphenyl)-(4-([(2-dimethylaminoethyl)-methylamino]methyl)phenyl)-methanone
-
 Homo sapiens
3.1.1.8 (3,4-dimethoxyphenyl)-(4-([(2-methoxybenzyl)methylamino]methyl)phenyl)-methanone
-
 Homo sapiens
3.1.1.8 (3,4-dimethoxyphenyl)-(4-([methyl-(3-methylbenzyl)amino]methyl)phenyl)methanone
-
 Homo sapiens
3.1.1.8 (3,4-dimethoxyphenyl)-(4-([methyl-(3-nitrobenzyl)amino]methyl)phenyl)methanone
-
 Homo sapiens
3.1.1.8 (4-([benzyl-(2-dimethylaminoethyl)amino]methyl)-phenyl)-(3,4-dimethoxyphenyl)methanone
-
 Homo sapiens
3.1.1.8 (4-([benzyl-(2-hydroxyethyl)amino]methyl)phenyl)-(3,4-dimethoxyphenyl)methanone
-
 Homo sapiens
3.1.1.8 (4-[(benzylethylamino)methyl]phenyl)-(3,4-dimethoxyphenyl)methanone
-
 Homo sapiens
3.1.1.8 (4-[(benzylmethylamino)methyl]phenyl)-(3,4-dimethoxyphenyl)methanone
-
 Homo sapiens
3.1.1.8 (4-[(benzylmethylamino)methyl]phenyl)-(3-fluoro-4-methoxyphenyl)methanone
-
 Homo sapiens
3.1.1.8 (4-[(benzylmethylamino)methyl]phenyl)-(4-methoxyphenyl)methanone
-
 Homo sapiens
3.1.1.8 (4-[3-(benzylmethylamino)propenyl]phenyl)-(3,4-dimethoxyphenyl)methanone
-
 Homo sapiens
3.1.1.8 donepezil
-
 Homo sapiens
3.1.1.8 additional information design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors, structure-based drug design, overview Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.7 extracellular
-
 Homo sapiens
-
-
3.1.1.8 extracellular
-
 Homo sapiens
-
-

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.7 Homo sapiens
-
-
-
3.1.1.8 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.7 serum
-
 Homo sapiens
-
3.1.1.8 serum
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.7 acetylthiocholine iodide + H2O detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB Homo sapiens acetate + thiocholine iodide
-
 ?
3.1.1.8 butyrylthiocholine iodide + H2O detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB Homo sapiens butyrate + thiocholine iodide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.7 AChE
-
 Homo sapiens
3.1.1.8 BChE
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.1.7 37
-
 assay at Homo sapiens
3.1.1.8 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.7 8
-
 assay at Homo sapiens
3.1.1.8 8
-
 assay at Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.1.7 0.00002
-
-
 Homo sapiens donepezil
3.1.1.7 0.00046
-
 pH 8.0, 37°C Homo sapiens (4-[(benzylmethylamino)methyl]phenyl)-(3,4-dimethoxyphenyl)methanone
3.1.1.7 0.0006
-
 pH 8.0, 37°C Homo sapiens (4-[(benzylethylamino)methyl]phenyl)-(3,4-dimethoxyphenyl)methanone
3.1.1.7 0.0014
-
 pH 8.0, 37°C Homo sapiens (4-([benzyl-(2-hydroxyethyl)amino]methyl)phenyl)-(3,4-dimethoxyphenyl)methanone
3.1.1.7 0.0016
-
 pH 8.0, 37°C Homo sapiens (4-[(benzylmethylamino)methyl]phenyl)-(3-fluoro-4-methoxyphenyl)methanone
3.1.1.7 0.0017
-
 pH 8.0, 37°C Homo sapiens (3,4-dimethoxyphenyl)-(4-([methyl-(3-methylbenzyl)amino]methyl)phenyl)methanone
3.1.1.7 0.0018
-
 pH 8.0, 37°C Homo sapiens (4-[(benzylmethylamino)methyl]phenyl)-(4-methoxyphenyl)methanone
3.1.1.7 0.0021
-
 pH 8.0, 37°C Homo sapiens (4-[3-(benzylmethylamino)propenyl]phenyl)-(3,4-dimethoxyphenyl)methanone
3.1.1.7 0.0024
-
 pH 8.0, 37°C Homo sapiens (3,4-dimethoxyphenyl)-(4-([(2-dimethylaminoethyl)-methylamino]methyl)phenyl)-methanone
3.1.1.7 0.0037
-
 pH 8.0, 37°C Homo sapiens (3,4-dimethoxyphenyl)-(4-([(2-methoxybenzyl)methylamino]methyl)phenyl)-methanone
3.1.1.7 0.0043
-
 pH 8.0, 37°C Homo sapiens (3,4-dimethoxyphenyl)-(4-([methyl-(3-nitrobenzyl)amino]methyl)phenyl)methanone
3.1.1.7 0.0086
-
 pH 8.0, 37°C Homo sapiens (4-([benzyl-(2-dimethylaminoethyl)amino]methyl)-phenyl)-(3,4-dimethoxyphenyl)methanone
3.1.1.7 0.0196
-
 pH 8.0, 37°C Homo sapiens (4-[(benzylmethylamino)methyl]phenyl)naphthalen-2-yl-methanone
3.1.1.7 0.0272
-
 pH 8.0, 37°C Homo sapiens (3,4-dimethoxyphenyl)-(4-[(methylprop-2-ynylamino)-methyl]phenyl)methanone
3.1.1.7 0.0368
-
 pH 8.0, 37°C Homo sapiens (3,4-dimethoxyphenyl)-(4-[(ethylpropylamino)methyl]phenyl)methanone
3.1.1.7 0.054
-
 pH 8.0, 37°C Homo sapiens [4-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)phenyl]-(3,4-dimethoxyphenyl)methanone
3.1.1.7 0.345
-
 pH 8.0, 37°C Homo sapiens (3,4-dimethoxyphenyl)-(4-morpholin-4-ylmethylphenyl)methanone
3.1.1.8 0.0074
-
-
 Homo sapiens donepezil
3.1.1.8 0.0162
-
 pH 8.0, 37°C Homo sapiens (3,4-dimethoxyphenyl)-(4-([(2-methoxybenzyl)methylamino]methyl)phenyl)-methanone
3.1.1.8 0.0332
-
 pH 8.0, 37°C Homo sapiens (4-([benzyl-(2-dimethylaminoethyl)amino]methyl)-phenyl)-(3,4-dimethoxyphenyl)methanone
3.1.1.8 0.044
-
 above, pH 8.0, 37°C Homo sapiens (4-[3-(benzylmethylamino)propenyl]phenyl)-(3,4-dimethoxyphenyl)methanone
3.1.1.8 0.0607
-
 pH 8.0, 37°C Homo sapiens (4-[(benzylmethylamino)methyl]phenyl)-(3,4-dimethoxyphenyl)methanone
3.1.1.8 0.0715
-
 pH 8.0, 37°C Homo sapiens (4-[(benzylethylamino)methyl]phenyl)-(3,4-dimethoxyphenyl)methanone
3.1.1.8 0.0888
-
 pH 8.0, 37°C Homo sapiens (3,4-dimethoxyphenyl)-(4-([(2-dimethylaminoethyl)-methylamino]methyl)phenyl)-methanone
3.1.1.8 0.1
-
 pH 8.0, 37°C Homo sapiens (4-[(benzylmethylamino)methyl]phenyl)-(3-fluoro-4-methoxyphenyl)methanone
3.1.1.8 0.1
-
 above, pH 8.0, 37°C Homo sapiens (3,4-dimethoxyphenyl)-(4-([methyl-(3-nitrobenzyl)amino]methyl)phenyl)methanone
3.1.1.8 0.1
-
 above, pH 8.0, 37°C Homo sapiens (4-[(benzylmethylamino)methyl]phenyl)-(4-methoxyphenyl)methanone
3.1.1.8 0.125
-
 pH 8.0, 37°C Homo sapiens (3,4-dimethoxyphenyl)-(4-([methyl-(3-methylbenzyl)amino]methyl)phenyl)methanone
3.1.1.8 0.172
-
 pH 8.0, 37°C Homo sapiens (4-([benzyl-(2-hydroxyethyl)amino]methyl)phenyl)-(3,4-dimethoxyphenyl)methanone