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Literature summary extracted from

  • Mayer, A.; Denanglaire, S.; Viollet, B.; Leo, O.; Andris, F.
    AMP-activated protein kinase regulates lymphocyte responses to metabolic stress but is largely dispensable for immune cell development and function (2008), Eur. J. Immunol., 38, 948-956.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.31 AMP
-
 Mus musculus
2.7.11.31 Calmodulin AMPK activation by phosphorylation through the Ca2+-calmodulin dependent protein kinase kinase, CaMKK Mus musculus
2.7.11.31 additional information T cell receptor stimulation activates AMPK due to energy needs in case of cell division having regulatory function, overview. AMPK activation by phosphorylation through the Ca2+-calmodulin dependent protein kinase kinase, CaMKK Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.31 AMPK is phylogenetically conserved Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.31 additional information construction of AMPKalpha1-KO mice, which show a splenomegaly possibly due to the massive amplification of erythroid nucleated cells, AMPKalpha1-KO mice are fully immunocompetent in vivo and display normal cell proliferation, humoral, cytotoxic and delayed-type hypersensitivity responses following antigen injection, phenotype, overview. AMPKalpha1-KO cells display increasing sensitivity to energetic stress in vitro, and are unable to maintain adequate ATP levels in response to ATP synthase inhibition, but the cells are able to respond to antigen stimulation in vitro, overview Mus musculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.31 Ca2+ AMPK activation by phosphorylation through the Ca2+-calmodulin dependent protein kinase kinase, CaMKK Mus musculus
2.7.11.31 Mg2+
-
 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.31 additional information Mus musculus AMP-activated protein kinase acts as an energy sensor able to adapt cellular metabolism in response to nutritional environmental variations, and it regulates lymphocyte responses to metabolic stress but is largely dispensable for immune cell development and function, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.31 Mus musculus
-
 wild-type C57BL/6 mice
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.31 liver
-
 Mus musculus
-
2.7.11.31 lymphocyte selective expression of the AMPKalpha1 catalytic subunit in lymphoid cells Mus musculus
-
2.7.11.31 splenocyte
-
 Mus musculus
-
2.7.11.31 thymus
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.31 additional information AMP-activated protein kinase acts as an energy sensor able to adapt cellular metabolism in response to nutritional environmental variations, and it regulates lymphocyte responses to metabolic stress but is largely dispensable for immune cell development and function, overview Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.31 AMP-activated protein kinase
-
 Mus musculus
2.7.11.31 AMPK
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.31 ATP
-
 Mus musculus