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Literature summary extracted from

  • Nief, N.; Le Morvan, V.; Robert, J.
    Involvement of gene polymorphisms of thymidylate synthase in gene expression, protein activity and anticancer drug cytotoxicity using the NCI-60 panel (2007), Eur. J. Cancer, 43, 955-962.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.1.1.45 medicine TYMS is the target enzyme of fluorouracil, an antimetabolite widely used in the treatment of colorectal, head-and-neck, breast cancers, pancreatic cancer and hepatocellular carcinoma Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.45 5-fluorouracil
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.45 5,10-methylenetetrahydrofolate + dUMP Homo sapiens it is a key enzyme for the synthesis of the DNA-specific nucleotide thymidylate 7,8-dihydrofolate + dTMP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.45 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.45 additional information NCI60 panel of 60 human tumor cell lines, the NCI-60 model is able to provide interesting information about the role of TYMS gene polymorphisms on TYMS mRNA expression and catalytic activity Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.45 5,10-methylenetetrahydrofolate + dUMP
-
 Homo sapiens 7,8-dihydrofolate + dTMP
-
 ?
2.1.1.45 5,10-methylenetetrahydrofolate + dUMP it is a key enzyme for the synthesis of the DNA-specific nucleotide thymidylate Homo sapiens 7,8-dihydrofolate + dTMP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.45 TYMS
-
 Homo sapiens