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Literature summary extracted from

  • Yi, K.D.; Simpkins, J.W.
    Protein phosphatase 1, protein phosphatase 2A, and calcineurin play a role in estrogen-mediated neuroprotection (2008), Endocrinology, 149, 5235-5243.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.3.16 estrogen estrogen maintains the function of isozymes PP1, PP2A, and calcineurin Rattus norvegicus
3.1.3.16 estrogen estrogen maintains the function of PP1, PP2A, and calcineurin Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.16 cyclosporin A specific inhibitor of calcineurin Homo sapiens
3.1.3.16 cyclosporin A specific inhibitor of calcineurin Rattus norvegicus
3.1.3.16 endothall specific inhibitor of isozyme PP2A Homo sapiens
3.1.3.16 endothall specific inhibitor of isozyme PP2A Rattus norvegicus
3.1.3.16 glutamate inhibitor of isozyme PP2A Homo sapiens
3.1.3.16 glutamate inhibitor of isozyme PP2A Rattus norvegicus
3.1.3.16 additional information protein phosphatase inhibitor II and cyclosporin A have no inhibitory effect on isozyme PP2A Homo sapiens
3.1.3.16 additional information protein phosphatase inhibitor II and cyclosporin A have no inhibitory effect on isozyme PP2A Rattus norvegicus
3.1.3.16 okadaic acid inhibitor of isozyme PP2A Homo sapiens
3.1.3.16 okadaic acid inhibitor of isozyme PP2A Rattus norvegicus
3.1.3.16 protein phosphatase inhibitor II specific inhibitor of isozyme PP1 Homo sapiens
3.1.3.16 protein phosphatase inhibitor II specific inhibitor of isozyme PP1 Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.3.16 32000
-
 isozyme PP1, SDS-PAGE Homo sapiens
3.1.3.16 32000
-
 isozyme PP2A, SDS-PAGE Homo sapiens
3.1.3.16 60000
-
 isozyme PP2B, SDS-PAGE Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.16 Homo sapiens
-
-
-
3.1.3.16 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.16 C6 glioma cell
-
 Rattus norvegicus
-
3.1.3.16 cerebral cortical neuron
-
 Rattus norvegicus
-
3.1.3.16 glioma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.16 phospho-threonylpeptide + H2O
-
 Homo sapiens threonylpeptide + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.16 calcineurin
-
 Homo sapiens
3.1.3.16 calcineurin
-
 Rattus norvegicus
3.1.3.16 PP1
-
 Homo sapiens
3.1.3.16 PP1
-
 Rattus norvegicus
3.1.3.16 PP2A
-
 Homo sapiens
3.1.3.16 PP2A
-
 Rattus norvegicus
3.1.3.16 PP2B
-
 Homo sapiens
3.1.3.16 PP2B
-
 Rattus norvegicus
3.1.3.16 protein phosphatase 1
-
 Homo sapiens
3.1.3.16 protein phosphatase 1
-
 Rattus norvegicus
3.1.3.16 protein phosphatase 2A
-
 Homo sapiens
3.1.3.16 protein phosphatase 2A
-
 Rattus norvegicus
3.1.3.16 protein phosphatase 2B
-
 Homo sapiens
3.1.3.16 protein phosphatase 2B
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
3.1.3.16 Calmodulin
-
 Homo sapiens
3.1.3.16 Calmodulin
-
 Rattus norvegicus