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Literature summary extracted from

  • Bianco, F.; Perrotta, C.; Novellino, L.; Francolini, M.; Riganti, L.; Menna, E.; Saglietti, L.; Schuchman, E.H.; Furlan, R.; Clementi, E.; Matteoli, M.; Verderio, C.
    Acid sphingomyelinase activity triggers microparticle release from glial cells (2009), EMBO J., 28, 1043-1054.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.1.4.12 medicine activation of acid sphingomyelinase is necessary and sufficient for microparticle release from glial cells and define key molecular effectors of microparticle formation and IL-1beta release, thus, opening new strategies for the treatment of neuroinflammatory diseases Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.12 additional information no inhibitory effect is observed in cultures treated with inhibitors of neutral SMase such as manumicyn (0.001 mM) or GW4869 (0.005 mM) Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.12 plasma membrane activated acid sphingomyelinase moves to plasma membrane outer leaflet Mus musculus 5886
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.12 additional information Mus musculus Src kinase-dependent phosphorylation of p38 MAPK is involved in P2X7-induced A-SMase activation, A-SMase mediates ATP receptor P2X7R-dependent microparticle shedding and P2X7-dependent IL-1beta release ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.12 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.12 astrocyte
-
 Mus musculus
-
3.1.4.12 microglia
-
 Mus musculus
-
3.1.4.12 N-9 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.12 additional information Src kinase-dependent phosphorylation of p38 MAPK is involved in P2X7-induced A-SMase activation, A-SMase mediates ATP receptor P2X7R-dependent microparticle shedding and P2X7-dependent IL-1beta release Mus musculus ?
-
 ?
3.1.4.12 sphingomyelin + H2O
-
 Mus musculus N-acylsphingosine + choline phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.12 A-SMase
-
 Mus musculus
3.1.4.12 acid sphingomyelinase
-
 Mus musculus