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Literature summary extracted from

  • Clarke, A.J.; Hurtado-Guerrero, R.; Pathak, S.; Schuettelkopf, A.W.; Borodkin, V.; Shepherd, S.M.; Ibrahim, A.F.; van Aalten, D.M.
    Structural insights into mechanism and specificity of O-GlcNAc transferase (2008), EMBO J., 27, 2780-2788.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.255 expressed in Escherichia coli Xanthomonas campestris
2.4.1.255 expressed in Escherichia coli Homo sapiens

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.4.1.255 X-ray crystallography Xanthomonas campestris
2.4.1.255 X-ray crystallography Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.4.1.255 D431A single-point mutation, peptide-binding mutant Homo sapiens
2.4.1.255 D925A single-point mutation, UDP-GlcNAc-binding mutant Homo sapiens
2.4.1.255 D925N single-point mutation, UDP-GlcNAc-binding mutant Homo sapiens
2.4.1.255 H498A single-point mutation, peptide-binding mutant Homo sapiens
2.4.1.255 K842M single-point mutation, UDP-GlcNAc-binding mutant Homo sapiens
2.4.1.255 K898A single-point mutation, UDP-GlcNAc-binding mutant Homo sapiens
2.4.1.255 N458A single-point mutation, peptide-binding mutant Homo sapiens
2.4.1.255 Q839A single-point mutation, UDP-GlcNAc-binding mutant Homo sapiens
2.4.1.255 R637A single-point mutation, peptide-binding mutant Homo sapiens
2.4.1.255 T560A single-point mutation, UDP-GlcNAc-binding mutant Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.255 Homo sapiens O15294
-
-
2.4.1.255 Xanthomonas campestris
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.1.255
-
 Xanthomonas campestris
2.4.1.255
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.255 UDP-GlcNAc + CKII peptide
-
 Xanthomonas campestris UDP + N-acetyl-D-glucosaminyl-[CKII peptide]
-
 ?
2.4.1.255 UDP-GlcNAc + TAB1 protein
-
 Xanthomonas campestris UDP + N-acetyl-D-glucosaminyl-[TAB1 protein]
-
 ?
2.4.1.255 UDP-GlcNAc + TAB1 protein
-
 Homo sapiens UDP + N-acetyl-D-glucosaminyl-[TAB1 protein]
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.255 hOGT
-
 Homo sapiens
2.4.1.255 O-GlcNAc transferase
-
 Xanthomonas campestris
2.4.1.255 O-GlcNAc transferase
-
 Homo sapiens
2.4.1.255 OGT
-
 Xanthomonas campestris
2.4.1.255 OGT
-
 Homo sapiens
2.4.1.255 XcOGT
-
 Xanthomonas campestris

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.1.255 37
-
 assay at Homo sapiens