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Literature summary extracted from

  • Shiratani, H.; Katoh, M.; Nakajima, M.; Yokoi, T.
    Species differences in UDP-glucuronosyltransferase activities in mice and rats (2008), Drug Metab. Dispos., 36, 1745-1752.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.17 0.035
-
 estradiol pH 7.4, 37°C Rattus norvegicus
2.4.1.17 0.042
-
 estradiol pH 7.4, 37°C Mus musculus
2.4.1.17 0.164
-
 4-Methylumbelliferone pH 7.4, 37°C Mus musculus
2.4.1.17 0.32
-
 morphine pH 7.4, 37°C Rattus norvegicus
2.4.1.17 0.34
-
 mycophenolate pH 7.4, 37°C Rattus norvegicus
2.4.1.17 0.416
-
 4-Methylumbelliferone pH 7.4, 37°C Rattus norvegicus
2.4.1.17 0.494
-
 4-nitrophenol above, pH 7.4, 37°C Rattus norvegicus
2.4.1.17 1.272
-
 mycophenolate pH 7.4, 37°C Mus musculus
2.4.1.17 1.5
-
 4-nitrophenol above, pH 7.4, 37°C Mus musculus
2.4.1.17 2.38
-
 morphine pH 7.4, 37°C Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.17 microsome
-
 Mus musculus
-
-
2.4.1.17 microsome
-
 Rattus norvegicus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.17 Mg2+
-
 Mus musculus
2.4.1.17 Mg2+
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.17 additional information Mus musculus comparison of murine and rat UGT activity and substrate specificity using duodenum and liver microsomes, overview ?
-
 ?
2.4.1.17 additional information Rattus norvegicus comparison of murine and rat UGT activity and substrate specificity using duodenum and liver microsomes, overview ?
-
 ?
2.4.1.17 UDP-D-glucuronate + 4-nitrophenol Mus musculus
-
 UDP + 4-nitrophenyl O-beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-D-glucuronate + 4-nitrophenol Rattus norvegicus
-
 UDP + 4-nitrophenyl O-beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-D-glucuronate + acceptor Mus musculus
-
 UDP + acceptor beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-D-glucuronate + acceptor Rattus norvegicus
-
 UDP + acceptor beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-D-glucuronate + estradiol Mus musculus
-
 UDP + estradiol 3-O-beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-D-glucuronate + estradiol Rattus norvegicus
-
 UDP + estradiol 3-O-beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-D-glucuronate + morphine Mus musculus
-
 UDP + morphine 3-O-beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-D-glucuronate + morphine Rattus norvegicus
-
 UDP + morphine 3-O-beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-D-glucuronate + mycophenolate Mus musculus
-
 UDP + ?
-
 ?
2.4.1.17 UDP-D-glucuronate + mycophenolate Rattus norvegicus
-
 UDP + ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Mus musculus
-
 C57BL/6J mic, BALB/c, C3H/HeJ, DBA/2, ddY, and ICR mice
-
2.4.1.17 Rattus norvegicus
-
 Sprague-Dawley rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.17 colon
-
 Mus musculus
-
2.4.1.17 colon
-
 Rattus norvegicus
-
2.4.1.17 duodenum
-
 Mus musculus
-
2.4.1.17 duodenum
-
 Rattus norvegicus
-
2.4.1.17 ileum
-
 Mus musculus
-
2.4.1.17 ileum
-
 Rattus norvegicus
-
2.4.1.17 jejunum
-
 Mus musculus
-
2.4.1.17 jejunum
-
 Rattus norvegicus
-
2.4.1.17 liver
-
 Mus musculus
-
2.4.1.17 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 additional information comparison of murine and rat UGT activity and substrate specificity using duodenum and liver microsomes, overview Mus musculus ?
-
 ?
2.4.1.17 additional information comparison of murine and rat UGT activity and substrate specificity using duodenum and liver microsomes, overview Rattus norvegicus ?
-
 ?
2.4.1.17 UDP-D-glucuronate + 4-methylumbelliferone
-
 Mus musculus UDP + 4-methylumbelliferyl beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-D-glucuronate + 4-methylumbelliferone
-
 Rattus norvegicus UDP + 4-methylumbelliferyl beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-D-glucuronate + 4-nitrophenol
-
 Mus musculus UDP + 4-nitrophenyl O-beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-D-glucuronate + 4-nitrophenol
-
 Rattus norvegicus UDP + 4-nitrophenyl O-beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-D-glucuronate + acceptor
-
 Mus musculus UDP + acceptor beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-D-glucuronate + acceptor
-
 Rattus norvegicus UDP + acceptor beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-D-glucuronate + estradiol
-
 Mus musculus UDP + estradiol 3-O-beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-D-glucuronate + estradiol
-
 Rattus norvegicus UDP + estradiol 3-O-beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-D-glucuronate + morphine
-
 Mus musculus UDP + morphine 3-O-beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-D-glucuronate + morphine
-
 Rattus norvegicus UDP + morphine 3-O-beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-D-glucuronate + mycophenolate
-
 Mus musculus UDP + ?
-
 ?
2.4.1.17 UDP-D-glucuronate + mycophenolate
-
 Rattus norvegicus UDP + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.17 UDP-glucuronosyltransferase
-
 Mus musculus
2.4.1.17 UDP-glucuronosyltransferase
-
 Rattus norvegicus
2.4.1.17 UGT
-
 Mus musculus
2.4.1.17 UGT
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.1.17 37
-
 assay at Mus musculus
2.4.1.17 37
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.17 7.4
-
 assay at Mus musculus
2.4.1.17 7.4
-
 assay at Rattus norvegicus