Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • de Lima-Bessa, K.M.; Armelini, M.G.; Chigancas, V.; Jacysyn, J.F.; Amarante-Mendes, G.P.; Sarasin, A.; Menck, C.F.
    CPDs and 6-4PPs play different roles in UV-induced cell death in normal and NER-deficient human cells (2008), DNA Repair, 7, 303-312.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.99.3 expressed in SV-40 transformed human fibroblasts Potorous tridactylus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.99.3 additional information Potorous tridactylus CPDs and 6-4PPs play different roles in UV-induced cell death in normal and NER-deficient human cells ?
-
 ?
4.1.99.13 additional information Homo sapiens cyclobutane pyrimidine dimer-photolyase (EC 4.1.99.3) or 6-4PP-photolyase are able to prevent UV-induced apoptosis in cells deficient for nucleotide excision repair to a similar extent, while in nucleotide excision repair-proficient cells UV-induced apoptosis is prevented only by cyclobutane pyrimidine dimer-photolyase, with no effects observed when pyrimidine-(6-4)-pyrimidone photoproducts are removed by the specific photolyase. Both cyclobutane pyrimidine dimers and pyrimidine-(6-4)-pyrimidone photoproducts contribute to UV-induced apoptosis in nucleotide excision repair-deficient cells, while in nucleotide excision repair-proficient cells, cyclobutane pyrimidine dimers are the only lesions responsible for UV-killing, probably due to the rapid repair of pyrimidine-(6-4)-pyrimidone photoproducts by nucleotide excision repair ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.99.3 Potorous tridactylus
-
-
-
4.1.99.13 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.99.13 fibroblast
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.99.3 cyclobutadipyrimidine in DNA
-
 Potorous tridactylus pyrimidine residues in DNA
-
 ?
4.1.99.3 additional information CPDs and 6-4PPs play different roles in UV-induced cell death in normal and NER-deficient human cells Potorous tridactylus ?
-
 ?
4.1.99.13 additional information cyclobutane pyrimidine dimer-photolyase (EC 4.1.99.3) or 6-4PP-photolyase are able to prevent UV-induced apoptosis in cells deficient for nucleotide excision repair to a similar extent, while in nucleotide excision repair-proficient cells UV-induced apoptosis is prevented only by cyclobutane pyrimidine dimer-photolyase, with no effects observed when pyrimidine-(6-4)-pyrimidone photoproducts are removed by the specific photolyase. Both cyclobutane pyrimidine dimers and pyrimidine-(6-4)-pyrimidone photoproducts contribute to UV-induced apoptosis in nucleotide excision repair-deficient cells, while in nucleotide excision repair-proficient cells, cyclobutane pyrimidine dimers are the only lesions responsible for UV-killing, probably due to the rapid repair of pyrimidine-(6-4)-pyrimidone photoproducts by nucleotide excision repair Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.99.3 CPD-photolyase
-
 Potorous tridactylus
4.1.99.3 CPDphr
-
 Potorous tridactylus
4.1.99.13 6-4PP-photolyase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.99.3 FADH2
-
 Potorous tridactylus