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Literature summary extracted from

  • Waldman, B.C.; Wang, Y.; Kilaru, K.; Yang, Z.; Bhasin, A.; Wyatt, M.D.; Waldman, A.S.
    Induction of intrachromosomal homologous recombination in human cells by raltitrexed, an inhibitor of thymidylate synthase (2008), DNA Repair, 7, 1624-1635.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.1.1.45 medicine the use of the TS inhibitor RTX in the treatment of colorectal cancer has been approved in Europe, Canada, Australia and Japan Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.45 raltitrexed RTX, a folate analog that is a specific inhibitor of TS; treatment can stimulate accurate recombination events in human cells. Gene conversions not associated with crossovers are specifically enhanced severalfold. Recombination events provoked by a double-strand break are not impacted by treatment with raltitrexed, nor is error-prone double-strand break repair via nonhomologous end-joining Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.45 5,10-methylenetetrahydrofolate + dUMP Homo sapiens during TS inhibition, TMP levels decrease with a subsequent increase in dUTP 7,8-dihydrofolate + dTMP
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Organism

EC Number Organism UniProt Comment Textmining
2.1.1.45 Homo sapiens
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.45 GM00637 cell normal human fibroblast cell line immortalized by SV40 Homo sapiens
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.45 5,10-methylenetetrahydrofolate + dUMP
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 Homo sapiens 7,8-dihydrofolate + dTMP
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 ?
2.1.1.45 5,10-methylenetetrahydrofolate + dUMP during TS inhibition, TMP levels decrease with a subsequent increase in dUTP Homo sapiens 7,8-dihydrofolate + dTMP
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 ?