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Literature summary extracted from

  • Sasamura, T.; Ishikawa, H.O.; Sasaki, N.; Higashi, S.; Kanai, M.; Nakao, S.; Ayukawa, T.; Aigaki, T.; Noda, K.; Miyoshi, E.; Taniguchi, N.; Matsuno, K.
    The O-fucosyltransferase O-fut1 is an extracellular component that is essential for the constitutive endocytic trafficking of Notch in Drosophila (2007), Development, 134, 1347-1356.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.4.1.221 additional information analysis of O-fut 1 homozygous mutant cells shows that O-fut1 is required for the endocytic transportation of Notch to the early endosome which is shown to be independent of the O-fucosyltransferase activity of O-fut1 Drosophila melanogaster
2.4.1.221 additional information O-fut 1 overexpression and analysis of O-fut 1 homozygous mutant cells indicates that O-fut 1 promotes the turnover of Notch, which consequently downregulates Notch signaling Drosophila melanogaster
2.4.1.221 additional information O-fut1 protein added to conditioned medium and endocytosed is sufficient to rescue normal Notch transportation to the early endosome in O-fut1 knockdown cells Drosophila melanogaster

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.221 Drosophila melanogaster
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Synonyms

EC Number Synonyms Comment Organism
2.4.1.221 O-fucosyltransferase O-fut 1
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Drosophila melanogaster
2.4.1.221 OFUT1
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Drosophila melanogaster