BRENDA - Enzyme Database

Unique structural motif supports mannosylphospho dolichol synthase: an important angiogenesis regulator

Baksi, K.; Tavarez-Pagan, J.J.; Martinez, J.A.; Banerjee, D.K.; Curr. Drug Targets 9, 262-271 (2008)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
2.4.1.83
8-bromo-cAMP
capillary endothelial cells treated with the cAMP enhancer 8-bromo-cAMP show a 20% and 30% higher activity after 24h and 32h, respectively
Bos taurus
Application
EC Number
Application
Commentary
Organism
2.4.1.83
medicine
increased DPMS activity through protein phosphorylation is a driving force for angiogenesis
Bos taurus
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
2.4.1.83
Mg2+
-
Bos taurus
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.4.1.83
Bos taurus
-
-
-
Posttranslational Modification
EC Number
Posttranslational Modification
Commentary
Organism
2.4.1.83
phosphoprotein
alignment of the amino acid sequence of bDPM1 with that of Homo sapiens, Schizosaccharomyces pombe, Saccharomyces cerevisiae and Ustilago maydis indicates the presence of a cAMP-dependent phosphorylation motif
Bos taurus
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.4.1.83
endothelial cell
-
Bos taurus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.4.1.83
GDP-mannose + dolichyl phosphate
-
691937
Bos taurus
GDP + dolichyl D-mannosyl phosphate
-
-
-
?
Temperature Optimum [C]
EC Number
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
2.4.1.83
37
-
assay at
Bos taurus
pH Optimum
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
2.4.1.83
7
-
assay at
Bos taurus
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
2.4.1.83
8-bromo-cAMP
capillary endothelial cells treated with the cAMP enhancer 8-bromo-cAMP show a 20% and 30% higher activity after 24h and 32h, respectively
Bos taurus
Application (protein specific)
EC Number
Application
Commentary
Organism
2.4.1.83
medicine
increased DPMS activity through protein phosphorylation is a driving force for angiogenesis
Bos taurus
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
2.4.1.83
Mg2+
-
Bos taurus
Posttranslational Modification (protein specific)
EC Number
Posttranslational Modification
Commentary
Organism
2.4.1.83
phosphoprotein
alignment of the amino acid sequence of bDPM1 with that of Homo sapiens, Schizosaccharomyces pombe, Saccharomyces cerevisiae and Ustilago maydis indicates the presence of a cAMP-dependent phosphorylation motif
Bos taurus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.4.1.83
endothelial cell
-
Bos taurus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.4.1.83
GDP-mannose + dolichyl phosphate
-
691937
Bos taurus
GDP + dolichyl D-mannosyl phosphate
-
-
-
?
Temperature Optimum [C] (protein specific)
EC Number
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
2.4.1.83
37
-
assay at
Bos taurus
pH Optimum (protein specific)
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
2.4.1.83
7
-
assay at
Bos taurus