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Literature summary extracted from

  • Sorich, M.J.; Smith, P.A.; Miners, J.O.; Mackenzie, P.I.; McKinnon, R.A.
    Recent advances in the in silico modelling of UDP glucuronosyltransferase substrates (2008), Curr. Drug Metab., 9, 60-69.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.17 the largest subfamily UGT2B is encoded by genes clustered on chromosome 4, most isozymes show genetic polymorphisms Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.17 3-hydroxyflavone three-dimensional QSAR-model of UGT1A1 substrate inhibition, binding structure and modelling, overview Homo sapiens
2.4.1.17 bilirubin three-dimensional QSAR-model of UGT1A1 substrate inhibition, binding structure and modelling, overview Homo sapiens
2.4.1.17 morphine three-dimensional QSAR-model of UGT1A1 substrate inhibition, binding structure and modelling, overview Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.17 additional information Rattus norvegicus the enzyme is involved in clearance and detoxification of many chemical compounds, overview ?
-
 ?
2.4.1.17 additional information Homo sapiens the enzyme is involved in clearance and detoxification of many chemical compounds, overview ?
-
 ?
2.4.1.17 UDP-alpha-D-glucuronate + 3-hydroxyflavone Homo sapiens isozyme UGT1A1 UDP + 3-[(beta-D-glucopyranurnosyl)oxy]-flavone
-
 ?
2.4.1.17 UDP-D-glucuronate + acceptor Rattus norvegicus
-
 UDP + acceptor beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-D-glucuronate + acceptor Homo sapiens
-
 UDP + acceptor beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-D-glucuronate + bilirubin Homo sapiens isozyme UGT1A1 UDP + bilirubin beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-D-glucuronate + morphine Homo sapiens isozyme UGT1A1 UDP + morphine 3-O-beta-D-glucuronoside
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Homo sapiens P22309 isozyme UGT1A1; 17 isozymes
-
2.4.1.17 Rattus norvegicus
-
 several isozymes
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.17 gastrointestinal tract
-
 Rattus norvegicus
-
2.4.1.17 gastrointestinal tract
-
 Homo sapiens
-
2.4.1.17 kidney
-
 Rattus norvegicus
-
2.4.1.17 kidney
-
 Homo sapiens
-
2.4.1.17 liver expression of most isozymes Rattus norvegicus
-
2.4.1.17 liver expression of most isozymes Homo sapiens
-
2.4.1.17 lung
-
 Rattus norvegicus
-
2.4.1.17 lung
-
 Homo sapiens
-
2.4.1.17 olfactory epithelium
-
 Rattus norvegicus
-
2.4.1.17 olfactory epithelium
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 additional information the enzyme is involved in clearance and detoxification of many chemical compounds, overview Rattus norvegicus ?
-
 ?
2.4.1.17 additional information the enzyme is involved in clearance and detoxification of many chemical compounds, overview Homo sapiens ?
-
 ?
2.4.1.17 additional information prediction of substrates for several isozymes by two dimensional-QSAR modelling, regioselective glucuronidation of isozymes, overview, substrate recognition, and multiple pharmacophore perception, overview Homo sapiens ?
-
 ?
2.4.1.17 UDP-alpha-D-glucuronate + 3-hydroxyflavone isozyme UGT1A1 Homo sapiens UDP + 3-[(beta-D-glucopyranurnosyl)oxy]-flavone
-
 ?
2.4.1.17 UDP-D-glucuronate + acceptor
-
 Rattus norvegicus UDP + acceptor beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-D-glucuronate + acceptor
-
 Homo sapiens UDP + acceptor beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-D-glucuronate + bilirubin isozyme UGT1A1 Homo sapiens UDP + bilirubin beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-D-glucuronate + morphine isozyme UGT1A1 Homo sapiens UDP + morphine 3-O-beta-D-glucuronoside
-
 ?

Subunits

EC Number Subunits Comment Organism
2.4.1.17 More prediction of protein-protein interactions between isozymes, in silico modelling Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.4.1.17 More the UGT superfamily is divided into two families, UGT1 and UGT2, the latter is divided into two subfamilies, UGT2A and UGT2B Rattus norvegicus
2.4.1.17 More the UGT superfamily is divided into two families, UGT1 and UGT2, the latter is divided into two subfamilies, UGT2A and UGT2B Homo sapiens
2.4.1.17 UDP glucuronosyltransferase
-
 Rattus norvegicus
2.4.1.17 UDP glucuronosyltransferase
-
 Homo sapiens
2.4.1.17 UGT
-
 Rattus norvegicus
2.4.1.17 UGT
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.1.17 0.0005
-
 bilirubin isozyme UGT1A1 Homo sapiens
2.4.1.17 0.09
-
 3-hydroxyflavone isozyme UGT1A1 Homo sapiens
2.4.1.17 9
-
 morphine isozyme UGT1A1 Homo sapiens