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Literature summary extracted from

  • Perez de Diego, R.; Lopez-Granados, E.; Rivera, J.; Ferreira, A.; Fontan, G.; Bravo, J.; Garcia Rodriguez, M.C.; Bolland, S.
    Naturally occurring Brutons tyrosine kinase mutations have no dominant negative effect in an X-linked agammaglobulinaemia cellular model (2008), Clin. Exp. Immunol., 152, 33-38.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.10.2 Lyn kinase as part of the activation process Lyn phosphorylates Btk in Tyr551, which is subsequently autophosphorylated in Tyr223 Homo sapiens

Application

EC Number Application Comment Organism
2.7.10.2 medicine X-linked agammaglobulinaemia is a primary immune deficiency characterized by lack of circulating mature B cells, hypogammaglobulinaemia and recurrent infections because of a mutations in the Btk gene Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.10.2 for transfection of DT40 lymphoma cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.7.10.2 F540S mutant, shows absence of Btk phosphorylation on Tyr223 Homo sapiens
2.7.10.2 K374N mutant, residual kinase activity is present Homo sapiens
2.7.10.2 K430E mutant, shows absence of Btk phosphorylation on Tyr223 Homo sapiens
2.7.10.2 R288W mutant, residual kinase activity is present Homo sapiens
2.7.10.2 R28C mutant Homo sapiens
2.7.10.2 R544G mutant, residual kinase activity is present Homo sapiens
2.7.10.2 R544S mutant, residual kinase activity is present Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.10.2 ATP + [protein]-L-tyrosine Homo sapiens
-
 ADP + [protein]-L-tyrosine phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.10.2 Homo sapiens Q06187
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.10.2 phosphoprotein
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.10.2 blood
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.10.2 ATP + [protein]-L-tyrosine
-
 Homo sapiens ADP + [protein]-L-tyrosine phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.10.2 Brutons tyrosine kinase
-
 Homo sapiens
2.7.10.2 Btk
-
 Homo sapiens