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Literature summary extracted from

  • Goldhoff, P.; Warrington, N.M.; Limbrick, D.D.; Hope, A.; Woerner, B.M.; Jackson, E.; Perry, A.; Piwnica-Worms, D.; Rubin, J.B.
    Targeted inhibition of cyclic AMP phosphodiesterase-4 promotes brain tumor regression (2008), Clin. Cancer Res., 14, 7717-7725.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.53 rolipram PDE4 inhibition by rolipram can promote regression of malignant brain tumors when administered as an adjunct to established therapies Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.53 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.53 brain
-
 Homo sapiens
-
3.1.4.53 DAOY cell
-
 Homo sapiens
-
3.1.4.53 ependymoma cell
-
 Homo sapiens
-
3.1.4.53 meningioma cell
-
 Homo sapiens
-
3.1.4.53 oligodendroglioma cell
-
 Homo sapiens
-
3.1.4.53 U-87MG cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.53 3',5'-cAMP + H2O
-
 Homo sapiens 5'-AMP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.53 cAMP phosphodiesterase-4
-
 Homo sapiens
3.1.4.53 cyclic AMP phosphodiesterase-4
-
 Homo sapiens
3.1.4.53 PDE4
-
 Homo sapiens
3.1.4.53 PDE4A subfamily of PDE4 Homo sapiens