Literature summary extracted from

Krzystek-Korpacka, M.; Boehm, D.; Matusiewicz, M.; Diakowska, D.; Grabowski, K.; Gamian, A.
Paraoxonase 1 (PON1) status in gastroesophageal malignancies and associated paraneoplastic syndromes - connection with inflammation (2008), Clin. Biochem., 41, 804-811.

Application

EC Number	Application	Comment	Organism
3.1.1.2	medicine	PON1 moderately indicates cancer presence and regional metastasis, PON1 activity decreases in gastroesophageal cancers and corresponds to inflammation severity and cancer-related anemia, PON1's arylesterase activity reflects anemia severity, being correlated with hemoglobin, hematocrit, and iron	Homo sapiens

Protein Variants

EC Number	Protein Variants	Comment	Organism
3.1.1.2	Q192R	paraoxon is less efficiently hydrolysed compared to the wild type enzyme	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.1.1.2	Homo sapiens	P27169	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.1.1.2	esophageal squamous cell carcinoma cell	-	Homo sapiens	-
3.1.1.2	gastroesophageal adenocarcinoma cell	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.1.1.2	phenyl acetate + H2O	arylesterase activity of PON1	Homo sapiens	phenol + acetate	-	?

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Release 2023.1 (January 2023)