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Literature summary extracted from

  • Avgeris, M.; Koutalellis, G.; Fragoulis, E.G.; Scorilas, A.
    Expression analysis and clinical utility of L-Dopa decarboxylase (DDC) inprostate cancer (2008), Clin. Biochem., 41, 1140-1149.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.1.1.28 additional information DDC is overexpressed, at the mRNA level, in the specimens from prostate cancer patients, in comparison to those from benign prostate hyperplasia patients. High expression levels of DDC are found more frequently in high Gleason's score tumors as well as in advanced stage patients. Homo sapiens

Application

EC Number Application Comment Organism
4.1.1.28 medicine potential of DDC expression, at the mRNA level, as a novel biomarker in prostate cancer Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.28 5-Hydroxytryptophan Homo sapiens
-
 Serotonin + CO2 neurotransmitter ?
4.1.1.28 L-Dopa Homo sapiens
-
 dopamine + CO2
-
 ?
4.1.1.28 additional information Homo sapiens L-dopa decarboxylase is a pyridoxal 5'-phosphate-dependent enzyme involved in many malignancies ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.28 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.1.28 PC-3 cell prostate cancer Homo sapiens
-
4.1.1.28 prostate cancer cell line LNCaP cell Homo sapiens
-
4.1.1.28 prostate gland total RNA is isolated from tissue specimens from benign prostate hyperplasia and prostate cancer patients Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.28 5-Hydroxytryptophan
-
 Homo sapiens Serotonin + CO2 neurotransmitter ?
4.1.1.28 L-Dopa
-
 Homo sapiens dopamine + CO2
-
 ?
4.1.1.28 additional information L-dopa decarboxylase is a pyridoxal 5'-phosphate-dependent enzyme involved in many malignancies Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
4.1.1.28 homodimer
-
 Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
4.1.1.28 AADC
-
 Homo sapiens
4.1.1.28 Aromatic L-amino acid decarboxylase
-
 Homo sapiens
4.1.1.28 DDC
-
 Homo sapiens
4.1.1.28 L-DOPA decarboxylase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.1.28 pyridoxal 5'-phosphate
-
 Homo sapiens