Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Bichlmaier, I.; Finel, M.; Sippl, W.; Yli-Kauhaluoma, J.
    Stereochemical and steric control of the UDP-glucuronosyltransferase-catalyzed conjugation reaction: a rational approach for the design of inhibitors for the human UGT2B7 (2007), ChemMedChem, 2, 1730-1740.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.17 expression of isozyme UGT2B7 as a His-tagged protein in baculovirus-infected insect cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.17 ((2R)-2-hydroxy-2-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]ethyl)phosphonic acid
-
 Homo sapiens
2.4.1.17 ((2S)-2-hydroxy-2-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]ethyl)phosphonic acid
-
 Homo sapiens
2.4.1.17 ((3R)-3-hydroxy-3-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propyl)phosphonic acid
-
 Homo sapiens
2.4.1.17 ((3S)-3-hydroxy-3-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propyl)phosphonic acid
-
 Homo sapiens
2.4.1.17 (1R)-1-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]but-3-en-1-ol
-
 Homo sapiens
2.4.1.17 (1R)-1-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]ethanol
-
 Homo sapiens
2.4.1.17 (1R)-1-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]prop-2-en-1-ol
-
 Homo sapiens
2.4.1.17 (1R)-1-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propan-1-ol
-
 Homo sapiens
2.4.1.17 (1R)-1-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propane-1,3-diol
-
 Homo sapiens
2.4.1.17 (1R)-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]but-3-en-1-ol
-
 Homo sapiens
2.4.1.17 (1R)-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]ethan
-
 Homo sapiens
2.4.1.17 (1R)-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]prop-2-en-1-ol
-
 Homo sapiens
2.4.1.17 (1R)-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propan-1-ol
-
 Homo sapiens
2.4.1.17 (1R)-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propane-1,3-diol
-
 Homo sapiens
2.4.1.17 (1R)-2,2-dimethyl-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propan-1-ol
-
 Homo sapiens
2.4.1.17 (1R)-2-chloro-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]ethanol
-
 Homo sapiens
2.4.1.17 (1R)-2-methyl-1-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propan-1-ol
-
 Homo sapiens
2.4.1.17 (1R)-2-methyl-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propan-1-ol
-
 Homo sapiens
2.4.1.17 (1S)-1-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propane-1,3-diol
-
 Homo sapiens
2.4.1.17 (1S)-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]but-3-en-1-ol
-
 Homo sapiens
2.4.1.17 (1S)-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]ethanol
-
 Homo sapiens
2.4.1.17 (1S)-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]prop-2-en-1-ol
-
 Homo sapiens
2.4.1.17 (1S)-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propan-1-ol
-
 Homo sapiens
2.4.1.17 (1S)-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propane-1,3-diol
-
 Homo sapiens
2.4.1.17 (1S)-2,2-dimethyl-1-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propan-1-ol
-
 Homo sapiens
2.4.1.17 (1S)-2,2-dimethyl-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propan-1-ol
-
 Homo sapiens
2.4.1.17 (1S)-2-chloro-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]ethanol
-
 Homo sapiens
2.4.1.17 (1S)-2-methyl-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propan-1-ol
-
 Homo sapiens
2.4.1.17 (2-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]ethyl)phosphonic acid
-
 Homo sapiens
2.4.1.17 (2E)-3-(4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl)prop-2-en-1-ol
-
 Homo sapiens
2.4.1.17 (2E)-3-(4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl)prop-2-enoic acid
-
 Homo sapiens
2.4.1.17 (2R)-3,3-dimethyl-2-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]butan-2-ol
-
 Homo sapiens
2.4.1.17 (2S)-2-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]but-3-en-2-ol
-
 Homo sapiens
2.4.1.17 (2S)-2-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]butan-2-ol
-
 Homo sapiens
2.4.1.17 (2S)-2-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]pent-4-en-2-ol
-
 Homo sapiens
2.4.1.17 (2S)-3-methyl-2-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]butan-2-ol
-
 Homo sapiens
2.4.1.17 (2Z)-3-(4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl)prop-2-en-1-ol
-
 Homo sapiens
2.4.1.17 (2Z)-3-(4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl)prop-2-enoic acid
-
 Homo sapiens
2.4.1.17 (3-(dimethylamino)-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propyl)phosphonic acid
-
 Homo sapiens
2.4.1.17 (3-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propyl)phosphonic acid
-
 Homo sapiens
2.4.1.17 (3R)-3-hydroxy-3-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propanoic acid
-
 Homo sapiens
2.4.1.17 (3R)-3-hydroxy-3-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propanoic acid
-
 Homo sapiens
2.4.1.17 (3S)-3-hydroxy-3-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propanoic acid
-
 Homo sapiens
2.4.1.17 (3S)-3-hydroxy-3-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propanoic acid
-
 Homo sapiens
2.4.1.17 (4-(dimethylamino)-2-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]butyl)phosphonic acid
-
 Homo sapiens
2.4.1.17 (9R)-4,8,8-trimethyldecahydro-1,4-methanoazulene-9-carboxylic acid
-
 Homo sapiens
2.4.1.17 (9S)-4,8,8-trimethyldecahydro-1,4-methanoazulene-9-carboxylic acid
-
 Homo sapiens
2.4.1.17 (R)-phenyl[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]methanol
-
 Homo sapiens
2.4.1.17 (S)-phenyl[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]methanol
-
 Homo sapiens
2.4.1.17 (S)-phenyl[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]methanol
-
 Homo sapiens
2.4.1.17 2-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]ethanol
-
 Homo sapiens
2.4.1.17 2-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propan-2-ol
-
 Homo sapiens
2.4.1.17 2-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]ethanol
-
 Homo sapiens
2.4.1.17 3-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propan-1-ol
-
 Homo sapiens
2.4.1.17 4-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]butan-1-ol
-
 Homo sapiens
2.4.1.17 4-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]butanoic acid
-
 Homo sapiens
2.4.1.17 4-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]butan-1-ol
-
 Homo sapiens
2.4.1.17 4-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]butanoic acid
-
 Homo sapiens
2.4.1.17 diethyl ((2R)-2-hydroxy-2-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]ethyl)phosphonate
-
 Homo sapiens
2.4.1.17 diethyl ((2S)-2-hydroxy-2-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]ethyl)phosphonate
-
 Homo sapiens
2.4.1.17 diethyl ((3R)-3-hydroxy-3-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propyl)phosphonate
-
 Homo sapiens
2.4.1.17 diethyl ((3S)-3-hydroxy-3-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propyl)phosphonate
-
 Homo sapiens
2.4.1.17 dimethyl ((3R)-3-hydroxy-3-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propyl)phosphonate
-
 Homo sapiens
2.4.1.17 dimethyl ((3S)-3-hydroxy-3-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propyl)phosphonate
-
 Homo sapiens
2.4.1.17 ethyl (3R)-3-hydroxy-3-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propanoate
-
 Homo sapiens
2.4.1.17 ethyl (3R)-3-hydroxy-3-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propanoate
-
 Homo sapiens
2.4.1.17 ethyl (3S)-3-hydroxy-3-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propanoate
-
 Homo sapiens
2.4.1.17 ethyl (3S)-3-hydroxy-3-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propanoate
-
 Homo sapiens
2.4.1.17 isolongifolol and derivatives of primary alcohol series or carboxylic/phosphonic acids and amines, inhibitory potency, overview Homo sapiens
2.4.1.17 longifolol and derivatives of primary alcohol series or carboxylic/phosphonic acids and amines, inhibitory potency, overview Homo sapiens
2.4.1.17 additional information detailed structure-activity relationships, the glucuronidation of substrate compounds is prevented by the introduction of bulky substituents such as isopropyl, tert-butyl, and phenyl groups, overview Homo sapiens
2.4.1.17 [(1E)-3-(4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl)prop-1-en-1-yl]phosphonic acid
-
 Homo sapiens
2.4.1.17 [(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]acetic acid
-
 Homo sapiens
2.4.1.17 [(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]methanol
-
 Homo sapiens
2.4.1.17 [(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]acetic acid
-
 Homo sapiens
2.4.1.17 [(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]methanol
-
 Homo sapiens
2.4.1.17 [(E)-2-(4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl)ethenyl]phosphonic acid
-
 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.17 Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.17 UDP-D-glucuronate + acceptor Homo sapiens
-
 UDP + acceptor beta-D-glucuronoside
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Homo sapiens
-
 isozyme UGT2B7
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 additional information detailed structure-activity relationships with respect to functionality, stereochemical properties, and steric features, with 3D-quantitative structure-activity relationship using comparative molecular similarity analysis, overview. The glucuronidation of substrate compounds is prevented by the introduction of bulky substituents such as isopropyl, tert-butyl, and phenyl groups, overview Homo sapiens ?
-
 ?
2.4.1.17 UDP-D-glucuronate + acceptor
-
 Homo sapiens UDP + acceptor beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-D-glucuronate + estriol
-
 Homo sapiens UDP + ?
-
 ?
2.4.1.17 UDP-D-glucuronate + isolongifolol the compound is substrate and competitive inhibitor Homo sapiens UDP + isolongifolol beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-D-glucuronate + longifolol the compound is substrate and competitive inhibitor Homo sapiens UDP + longifolol beta-D-glucuronoside
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.17 UDP-glucuronosyltransferase 2B7
-
 Homo sapiens
2.4.1.17 UGT2B7
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.1.17 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.17 7.4
-
 assay at Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.1.17 0.000023
-
 isolongifolol
-
 Homo sapiens
2.4.1.17 0.000026
-
 longifolol
-
 Homo sapiens