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Literature summary extracted from

  • Fonvielle, M.; Coincon, M.; Daher, R.; Desbenoit, N.; Kosieradzka, K.; Barilone, N.; Gicquel, B.; Sygusch, J.; Jackson, M.; Therisod, M.
    Synthesis and biochemical evaluation of selective inhibitors of class II fructose bisphosphate aldolases: towards new synthetic antibiotics (2008), Chemistry, 14, 8521-8529.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
4.1.2.13
-
 Helicobacter pylori

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.2.13 N-(3-hydroxypropyl)-glycolohydrazide-bisphosphate fructose-1,6-bisphosphate analogue Helicobacter pylori
4.1.2.13 N-(3-hydroxypropyl)-glycolohydrazide-bisphosphate fructose-1,6-bisphosphate analogue Mycobacterium tuberculosis
4.1.2.13 N-(3-hydroxypropyl)-glycolohydrazide-bisphosphate fructose-1,6-bisphosphate analogue Oryctolagus cuniculus
4.1.2.13 N-(3-hydroxypropyl)-glycolohydrazide-bisphosphate fructose-1,6-bisphosphate analogue Saccharomyces cerevisiae
4.1.2.13 N-(3-hydroxypropyl)-glycolohydroxamic acid bisphosphate fructose-1,6-bisphosphate analogue, best results Helicobacter pylori
4.1.2.13 N-(3-hydroxypropyl)-glycolohydroxamic acid bisphosphate fructose-1,6-bisphosphate analogue, weakly active Mycobacterium tuberculosis
4.1.2.13 N-(3-hydroxypropyl)-glycolohydroxamic acid bisphosphate fructose-1,6-bisphosphate analogue, best results Oryctolagus cuniculus
4.1.2.13 N-(3-hydroxypropyl)-glycolohydroxamic acid bisphosphate fructose-1,6-bisphosphate analogue, best results Saccharomyces cerevisiae
4.1.2.13 N-(3-hydroxypropyl)-phosphoglycolohydroxamic acid fructose-1,6-bisphosphate analogue Helicobacter pylori
4.1.2.13 N-(3-hydroxypropyl)-phosphoglycolohydroxamic acid fructose-1,6-bisphosphate analogue Mycobacterium tuberculosis
4.1.2.13 N-(3-hydroxypropyl)-phosphoglycolohydroxamic acid fructose-1,6-bisphosphate analogue Oryctolagus cuniculus
4.1.2.13 N-(3-hydroxypropyl)-phosphoglycolohydroxamic acid fructose-1,6-bisphosphate analogue Saccharomyces cerevisiae
4.1.2.13 phosphoglycoloamidoxime dihydroxyacetone phosphate analogue Helicobacter pylori
4.1.2.13 phosphoglycoloamidoxime dihydroxyacetone phosphate analogue Mycobacterium tuberculosis
4.1.2.13 phosphoglycoloamidoxime dihydroxyacetone phosphate analogue Oryctolagus cuniculus
4.1.2.13 phosphoglycoloamidoxime dihydroxyacetone phosphate analogue Saccharomyces cerevisiae
4.1.2.13 phosphoglycolohydrazide dihydroxyacetone phosphate analogue Helicobacter pylori
4.1.2.13 phosphoglycolohydrazide dihydroxyacetone phosphate analogue Mycobacterium tuberculosis
4.1.2.13 phosphoglycolohydrazide dihydroxyacetone phosphate analogue Oryctolagus cuniculus
4.1.2.13 phosphoglycolohydrazide dihydroxyacetone phosphate analogue Saccharomyces cerevisiae

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.2.13 0.05
-
 D-fructose-1,6-bisphosphate
-
 Helicobacter pylori
4.1.2.13 0.055
-
 D-fructose-1,6-bisphosphate
-
 Oryctolagus cuniculus
4.1.2.13 0.45
-
 D-fructose-1,6-bisphosphate
-
 Saccharomyces cerevisiae

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.1.2.13 Co2+
-
 Mycobacterium tuberculosis
4.1.2.13 Co2+
-
 Oryctolagus cuniculus
4.1.2.13 Co2+
-
 Saccharomyces cerevisiae
4.1.2.13 Co2+
-
 Helicobacter pylori
4.1.2.13 Zn2+
-
 Mycobacterium tuberculosis
4.1.2.13 Zn2+
-
 Oryctolagus cuniculus
4.1.2.13 Zn2+
-
 Saccharomyces cerevisiae
4.1.2.13 Zn2+
-
 Helicobacter pylori

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.2.13 D-fructose-1,6-bisphosphate Mycobacterium tuberculosis
-
 dihydroxyacetone phosphate + glyceraldehyde-3-phosphate
-
 r
4.1.2.13 D-fructose-1,6-bisphosphate Oryctolagus cuniculus
-
 dihydroxyacetone phosphate + glyceraldehyde-3-phosphate
-
 r
4.1.2.13 D-fructose-1,6-bisphosphate Saccharomyces cerevisiae
-
 dihydroxyacetone phosphate + glyceraldehyde-3-phosphate
-
 r
4.1.2.13 D-fructose-1,6-bisphosphate Helicobacter pylori
-
 dihydroxyacetone phosphate + glyceraldehyde-3-phosphate
-
 r
4.1.2.13 D-fructose-1,6-bisphosphate Mycobacterium tuberculosis H37Rv
-
 dihydroxyacetone phosphate + glyceraldehyde-3-phosphate
-
 r

Organism

EC Number Organism UniProt Comment Textmining
4.1.2.13 Helicobacter pylori P56109
-
-
4.1.2.13 Mycobacterium tuberculosis P9WQA3
-
-
4.1.2.13 Mycobacterium tuberculosis H37Rv P9WQA3
-
-
4.1.2.13 Oryctolagus cuniculus P00883
-
-
4.1.2.13 Saccharomyces cerevisiae P14540
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.2.13 muscle
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.2.13 D-fructose-1,6-bisphosphate
-
 Mycobacterium tuberculosis dihydroxyacetone phosphate + glyceraldehyde-3-phosphate
-
 r
4.1.2.13 D-fructose-1,6-bisphosphate
-
 Oryctolagus cuniculus dihydroxyacetone phosphate + glyceraldehyde-3-phosphate
-
 r
4.1.2.13 D-fructose-1,6-bisphosphate
-
 Saccharomyces cerevisiae dihydroxyacetone phosphate + glyceraldehyde-3-phosphate
-
 r
4.1.2.13 D-fructose-1,6-bisphosphate
-
 Helicobacter pylori dihydroxyacetone phosphate + glyceraldehyde-3-phosphate
-
 r
4.1.2.13 D-fructose-1,6-bisphosphate
-
 Mycobacterium tuberculosis H37Rv dihydroxyacetone phosphate + glyceraldehyde-3-phosphate
-
 r

Synonyms

EC Number Synonyms Comment Organism
4.1.2.13 class I fructose bisphosphate aldolase
-
 Oryctolagus cuniculus
4.1.2.13 class II fructose bisphosphate aldolase
-
 Mycobacterium tuberculosis
4.1.2.13 class II fructose bisphosphate aldolase
-
 Saccharomyces cerevisiae
4.1.2.13 class II fructose bisphosphate aldolase
-
 Helicobacter pylori
4.1.2.13 FBA
-
 Mycobacterium tuberculosis
4.1.2.13 FBA
-
 Oryctolagus cuniculus
4.1.2.13 FBA
-
 Saccharomyces cerevisiae
4.1.2.13 FBA
-
 Helicobacter pylori