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Literature summary extracted from

  • Tuin, A.W.; Mol, M.A.; van den Berg, R.M.; Fidder, A.; van der Marel, G.A.; Overkleeft, H.S.; Noort, D.
    Activity-based protein profiling reveals broad reactivity of the nerve agent sarin (2009), Chem. Res. Toxicol., 22, 683-689.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.2.12 11-([5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl]amino)undecyl methylphosphonofluoridoate
-
 Homo sapiens
3.1.2.12 sarin strong inhibition at 0.0008 mM Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.2.12 additional information Homo sapiens esterase D/S-formylglutathione hydrolase plays a key role in glutathione-dependent detoxification of endogenously formed formaldehyde as well as in hydrolysis of various xenobiotics ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.2.12 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.2.12 blood plasma
-
 Homo sapiens
-
3.1.2.12 liver
-
 Homo sapiens
-
3.1.2.12 lung
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.2.12 additional information esterase D/S-formylglutathione hydrolase plays a key role in glutathione-dependent detoxification of endogenously formed formaldehyde as well as in hydrolysis of various xenobiotics Homo sapiens ?
-
 ?
3.1.2.12 S-formylglutathione + H2O
-
 Homo sapiens glutathione + formate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.2.12 esterase D/S-formylglutathione hydrolase
-
 Homo sapiens