BRENDA - Enzyme Database

Activity-based protein profiling reveals broad reactivity of the nerve agent sarin

Tuin, A.W.; Mol, M.A.; van den Berg, R.M.; Fidder, A.; van der Marel, G.A.; Overkleeft, H.S.; Noort, D.; Chem. Res. Toxicol. 22, 683-689 (2009)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.2.12
11-([5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl]amino)undecyl methylphosphonofluoridoate
-
Homo sapiens
3.1.2.12
sarin
strong inhibition at 0.0008 mM
Homo sapiens
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.1.2.12
additional information
Homo sapiens
esterase D/S-formylglutathione hydrolase plays a key role in glutathione-dependent detoxification of endogenously formed formaldehyde as well as in hydrolysis of various xenobiotics
?
-
-
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.1.2.12
Homo sapiens
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.2.12
blood plasma
-
Homo sapiens
-
3.1.2.12
liver
-
Homo sapiens
-
3.1.2.12
lung
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.2.12
additional information
esterase D/S-formylglutathione hydrolase plays a key role in glutathione-dependent detoxification of endogenously formed formaldehyde as well as in hydrolysis of various xenobiotics
691781
Homo sapiens
?
-
-
-
-
3.1.2.12
S-formylglutathione + H2O
-
691781
Homo sapiens
glutathione + formate
-
-
-
?
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.2.12
11-([5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl]amino)undecyl methylphosphonofluoridoate
-
Homo sapiens
3.1.2.12
sarin
strong inhibition at 0.0008 mM
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.1.2.12
additional information
Homo sapiens
esterase D/S-formylglutathione hydrolase plays a key role in glutathione-dependent detoxification of endogenously formed formaldehyde as well as in hydrolysis of various xenobiotics
?
-
-
-
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.2.12
blood plasma
-
Homo sapiens
-
3.1.2.12
liver
-
Homo sapiens
-
3.1.2.12
lung
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.2.12
additional information
esterase D/S-formylglutathione hydrolase plays a key role in glutathione-dependent detoxification of endogenously formed formaldehyde as well as in hydrolysis of various xenobiotics
691781
Homo sapiens
?
-
-
-
-
3.1.2.12
S-formylglutathione + H2O
-
691781
Homo sapiens
glutathione + formate
-
-
-
?