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Literature summary extracted from

  • Coe, K.J.; Jia, Y.; Ho, H.K.; Rademacher, P.; Bammler, T.K.; Beyer, R.P.; Farin, F.M.; Woodke, L.; Plymate, S.R.; Fausto, N.; Nelson, S.D.
    Comparison of the cytotoxicity of the nitroaromatic drug flutamide to its cyano analogue in the hepatocyte cell line TAMH: evidence for complex I inhibition and mitochondrial dysfunction using toxicogenomic screening (2007), Chem. Res. Toxicol., 20, 1277-1290.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.1.1.2 flutamide inhibits complex I of the electron transport chain to a greater extent than a nitro to cyano analogue of flutamide. As compared to the nitro to cyano analogue of flutamide, the nitroaromatic group of flutamide enhances cytotoxicity to hepatocytes, likely through mechanisms involving mitochondrial dysfunction and ATP depletion that include complex I inhibition Mus musculus
7.1.1.2 rotenone is a more potent inhibitor of complex I than flutamide. Inhibits complex I of the electron transport chain to a greater extent than a nitro to cyano analogue of flutamide Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.1.1.2 mitochondrion
-
 Mus musculus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
7.1.1.2 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.1.1.2 TAMH cell TGFalpha-transfected mouse hepatocyte cell line Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.1.1.2 decyl-ubiquinone + NADH + H+
-
 Mus musculus decyl-ubiquinol + NAD+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.1.1.2 complex I
-
 Mus musculus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
7.1.1.2 0.15
-
-
 Mus musculus flutamide