Any feedback?
Literature summary extracted from
- Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase: a chemistry-biology interdisciplinary study of the proteins structure-function-reaction mechanism relationships (2008), Chem. Rec., 8, 302-325.
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 5.4.99.7 | F699T | the mutant produces novel protosta-13(17),24-dien-3beta-ol as the sole truncated rearrangement product from (S)-2,3-oxidosqualene | Saccharomyces cerevisiae |
| 5.4.99.7 | H234W/Y510V | the mutant produces achilleol A, (13H)-isomalabarica-14(26),17E,21-trien-3beta-ol, and lanosterol at a 2:8:90 ratio from (S)-2,3-oxidosqualene | Saccharomyces cerevisiae |
| 5.4.99.7 | H234W/Y510W | mutant produces achilleol A from (S)-2,3-oxidosqualene | Saccharomyces cerevisiae |
| 5.4.99.7 | H234Y/Y510A | the mutant produces lanosterol from (S)-2,3-oxidosqualene (wild type reaction) | Saccharomyces cerevisiae |
| 5.4.99.7 | Y510K | inactive | Saccharomyces cerevisiae |
| 5.4.99.7 | Y510W | inactive | Saccharomyces cerevisiae |
| 5.4.99.7 | Y707X | the mutant produces (9R,10S)-polypoda-8(26),13E,17E,21-tetraen-3beta-ol, in addition to lanosterol, parkeol, and 9beta-lanosta-7,24-dien-3beta-ol from (S)-2,3-oxidosqualene | Saccharomyces cerevisiae |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.4.99.7 | 10,15-desdimethyl-2,3-oxidosqualene | - |
Saccharomyces cerevisiae |  |
| 5.4.99.7 | 10-desmethyl-2,3-oxidosqualene | - |
Saccharomyces cerevisiae | |
| 5.4.99.7 | 6-desmethyl-2,3-oxidosqualene | - |
Saccharomyces cerevisiae | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.4.99.7 | Saccharomyces cerevisiae | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.4.99.7 | (S)-2,3-oxidosqualene | - |
Saccharomyces cerevisiae | lanosterol | - |
? | |
| 5.4.99.7 | 2,3:22,23-diepoxysqualene | - |
Saccharomyces cerevisiae | 24(S),25-epoxylanosterol | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 5.4.99.7 | ERG7 | - |
Saccharomyces cerevisiae |
| 5.4.99.7 | Oxidosqualene-lanosterol cyclase | - |
Saccharomyces cerevisiae |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
