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Literature summary extracted from

  • Koch, K.; van den Berg, R.J.; Nieuwland, P.J.; Wijtmans, R.; Wubbolts, M.G.; Schoemaker, H.E.; Rutjes, F.P.; van Hest, J.C.
    Enzymatic synthesis of optically pure cyanohydrins in microchannels using a crude cell lysate (2008), Chem. Eng. J., 135, S89-S92.
No PubMed abstract available

Application

EC Number Application Comment Organism
4.1.2.47 synthesis crude cell lysate containing a hydroxynitrile lyase can be used for the enantioselective synthesis of several cyanohydrins in a microchannel. These enzymatic reactions show a high initial reaction rate and enantioselectivity, which in a batchwise process can only be achieved by vigorous stirring Hevea brasiliensis

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.2.47 expressed in the yeast strain Pichia pastoris Hevea brasiliensis

Organism

EC Number Organism UniProt Comment Textmining
4.1.2.47 Hevea brasiliensis
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.2.47 cell lysate
-
 Hevea brasiliensis
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.2.47 cyanide + 3-phenylpropanal
-
 Hevea brasiliensis (2S)-2-hydroxy-4-phenylbutanenitrile
-
 ?
4.1.2.47 cyanide + 4-methoxybenzaldehyde
-
 Hevea brasiliensis (2S)-4-methoxymandelonitrile
-
 ?
4.1.2.47 cyanide + benzaldehyde
-
 Hevea brasiliensis (S)-mandelonitrile
-
 ?
4.1.2.47 cyanide + thiophene-2-carbaldehyde
-
 Hevea brasiliensis (2S)-hydroxy(thiophen-2-yl)ethanenitrile
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.2.47 (S)-HbHNL
-
 Hevea brasiliensis
4.1.2.47 (S)-selective hydroxynitrile lyase
-
 Hevea brasiliensis
4.1.2.47 Hydroxynitrile lyase
-
 Hevea brasiliensis