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Literature summary extracted from

  • Gao, Y.; LaFleur, D.; Shah, R.; Zhao, Q.; Singh, M.; Brimijoin, S.
    An albumin-butyrylcholinesterase for cocaine toxicity and addiction: catalytic and pharmacokinetic properties (2008), Chem. Biol. Interact., 175, 83-87.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
3.1.1.8 additional information construction of a a quadruple mutant cocaine hydrolase CocH with improved catalytic efficiency for cocaine, the mutant enzyme is expressed as albumin fusion protein and introduced in rats, male and female Wistar rats, showing enzyme activity but also high enzyme decay rates Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.8 acetylthiocholine + H2O Homo sapiens
-
 acetate + thiocholine
-
 ?
3.1.1.8 butyrylthiocholine + H2O Homo sapiens
-
 butyrate + thiocholine
-
 ?
3.1.1.8 cocaine + H2O Homo sapiens
-
 ecgonine methyl ester + benzoate
-
 ?
3.1.1.8 additional information Homo sapiens butyrylcholinesterase is important in human cocaine metabolism despite its limited ability to hydrolyze this drug, it is a major contributor to cocaine metabolism and detoxification ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.8 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.8 blood plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.8 acetylthiocholine + H2O
-
 Homo sapiens acetate + thiocholine
-
 ?
3.1.1.8 butyrylthiocholine + H2O
-
 Homo sapiens butyrate + thiocholine
-
 ?
3.1.1.8 cocaine + H2O
-
 Homo sapiens ecgonine methyl ester + benzoate
-
 ?
3.1.1.8 additional information butyrylcholinesterase is important in human cocaine metabolism despite its limited ability to hydrolyze this drug, it is a major contributor to cocaine metabolism and detoxification Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.1.8 monomer BChE tetrameric forms are much longer-lived than monomers Homo sapiens
3.1.1.8 tetramer BChE tetrameric forms are much longer-lived than monomers Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.1.1.8 BChE
-
 Homo sapiens
3.1.1.8 butyrylcholinesterase
-
 Homo sapiens