Literature summary extracted from

Cheng, X.; Wang, D.; Jiang, L.; Yang, D.
DNA topoisomerase I inhibitory alkaloids from Corydalis saxicola (2008), Chem. Biodivers., 5, 1335-1344.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
5.6.2.1	(+)-cheilanthifoline	very weak inhibition	Homo sapiens
5.6.2.1	(+)-isocorydine	-	Homo sapiens
5.6.2.1	(-)-cavidine	very weak inhibition	Homo sapiens
5.6.2.1	(-)-pallidine	comparable to camptothecin	Homo sapiens
5.6.2.1	(-)-scoulerine	inhibition comparable to camptothecin	Homo sapiens
5.6.2.1	(-)-tetrahydropalmatine	very weak inhibition	Homo sapiens
5.6.2.1	Berberine	moderate inhibition	Homo sapiens
5.6.2.1	camptothecin	-	Homo sapiens
5.6.2.1	chelerythrine	-	Homo sapiens
5.6.2.1	corypalline	moderate inhibition	Homo sapiens
5.6.2.1	dehydrocavidine	moderate inhibition	Homo sapiens
5.6.2.1	dehydrocheilanthifoline	moderate inhibition	Homo sapiens
5.6.2.1	dehydrodiscretamine	moderate inhibition	Homo sapiens
5.6.2.1	feruloyl agmatine	moderate inhibition	Homo sapiens
5.6.2.1	palmatine	moderate inhibition	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
5.6.2.1	Homo sapiens	-	-	-

Synonyms

EC Number	Synonyms	Comment	Organism
5.6.2.1	DNA topoisomerase I	-	Homo sapiens

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Release 2023.1 (January 2023)