BRENDA - Enzyme Database

DNA topoisomerase I inhibitory alkaloids from Corydalis saxicola

Cheng, X.; Wang, D.; Jiang, L.; Yang, D.; Chem. Biodivers. 5, 1335-1344 (2008)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
5.6.2.1
(+)-cheilanthifoline
very weak inhibition
Homo sapiens
5.6.2.1
(+)-isocorydine
-
Homo sapiens
5.6.2.1
(-)-cavidine
very weak inhibition
Homo sapiens
5.6.2.1
(-)-pallidine
comparable to camptothecin
Homo sapiens
5.6.2.1
(-)-scoulerine
inhibition comparable to camptothecin
Homo sapiens
5.6.2.1
(-)-tetrahydropalmatine
very weak inhibition
Homo sapiens
5.6.2.1
Berberine
moderate inhibition
Homo sapiens
5.6.2.1
camptothecin
-
Homo sapiens
5.6.2.1
chelerythrine
-
Homo sapiens
5.6.2.1
corypalline
moderate inhibition
Homo sapiens
5.6.2.1
dehydrocavidine
moderate inhibition
Homo sapiens
5.6.2.1
dehydrocheilanthifoline
moderate inhibition
Homo sapiens
5.6.2.1
dehydrodiscretamine
moderate inhibition
Homo sapiens
5.6.2.1
feruloyl agmatine
moderate inhibition
Homo sapiens
5.6.2.1
palmatine
moderate inhibition
Homo sapiens
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
5.6.2.1
Homo sapiens
-
-
-
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
5.6.2.1
(+)-cheilanthifoline
very weak inhibition
Homo sapiens
5.6.2.1
(+)-isocorydine
-
Homo sapiens
5.6.2.1
(-)-cavidine
very weak inhibition
Homo sapiens
5.6.2.1
(-)-pallidine
comparable to camptothecin
Homo sapiens
5.6.2.1
(-)-scoulerine
inhibition comparable to camptothecin
Homo sapiens
5.6.2.1
(-)-tetrahydropalmatine
very weak inhibition
Homo sapiens
5.6.2.1
Berberine
moderate inhibition
Homo sapiens
5.6.2.1
camptothecin
-
Homo sapiens
5.6.2.1
chelerythrine
-
Homo sapiens
5.6.2.1
corypalline
moderate inhibition
Homo sapiens
5.6.2.1
dehydrocavidine
moderate inhibition
Homo sapiens
5.6.2.1
dehydrocheilanthifoline
moderate inhibition
Homo sapiens
5.6.2.1
dehydrodiscretamine
moderate inhibition
Homo sapiens
5.6.2.1
feruloyl agmatine
moderate inhibition
Homo sapiens
5.6.2.1
palmatine
moderate inhibition
Homo sapiens