Literature summary extracted from

Zhang, D.Y.; Wang, Y.; Lau, C.P.; Tse, H.F.; Li, G.R.
Both EGFR kinase and Src-related tyrosine kinases regulate human ether-a-go-go-related gene potassium channels (2008), Cell. Signal., 20, 1815-1821.

Application

EC Number	Application	Comment	Organism
2.7.10.1	medicine	human ether-a-go-go-related gene channels are regulated by EGFR kinase and Src-family kinases. EGFR kinase likely works on residue Y611. Regulation of human ether-a-go-go-related gene channels by protein tyrosine kinases likely modifies the channel activity and thus alters electrophysiological properties including action potential duration and cell excitability in human heart and neurons	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.7.10.1	AG556	highly selective EGFR kinase inhibitor, 0.01 mM inhibits human ether-a-go-go-related gene channel current and the effect is significantly countered by the protein tyrosine phosphatase inhibitor orthovanadate (1 mM)	Homo sapiens
2.7.10.1	genistein	broad-spectrum protein tyrosine kinase inhibitor, 0.03 mM inhibits human ether-a-go-go-related gene channel current and the effect is significantly countered by the protein tyrosine phosphatase inhibitor orthovanadate (1 mM)	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.7.10.1	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.7.10.1	HEK-293 cell	-	Homo sapiens	-

Synonyms

EC Number	Synonyms	Comment	Organism
2.7.10.1	EGFR kinase	-	Homo sapiens
2.7.10.1	epidermal growth factor receptor kinase	-	Homo sapiens

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Release 2023.1 (January 2023)