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Literature summary extracted from

  • Herget, S.; Lohse, M.J.; Nikolaev, V.O.
    Real-time monitoring of phosphodiesterase inhibition in intact cells (2008), Cell. Signal., 20, 1423-1431.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.4.17 Epac1-camps-PDE3A fusion protein is expressed in HEK-293 cells Homo sapiens
3.1.4.53 Epac1-camps-PDE4A1 fusion protein is expressed in HEK-293 cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.17 Cilostamide
-
 Homo sapiens
3.1.4.17 IBMX
-
 Homo sapiens
3.1.4.17 Milrinone
-
 Homo sapiens
3.1.4.17 additional information not inhibited by rolipram and sildenafil Homo sapiens
3.1.4.53 3-isobuytl-1-methylxanthine
-
 Homo sapiens
3.1.4.53 Ro20-1724 PDE4 inhibitor Homo sapiens
3.1.4.53 rolipram PDE4 inhibitor Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.17 Homo sapiens P27815
-
-
3.1.4.53 Homo sapiens P27815
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.17 3',5'-cAMP + H2O
-
 Homo sapiens 5'-AMP
-
 ?
3.1.4.17 3',5'-cGMP + H2O
-
 Homo sapiens 5'-GMP
-
 ?
3.1.4.53 3',5'-cAMP + H2O
-
 Homo sapiens 5'-AMP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.17 PDE3
-
 Homo sapiens
3.1.4.17 PDE3A isoform Homo sapiens
3.1.4.53 PDE4
-
 Homo sapiens
3.1.4.53 PDE4A1 isoform Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.4.17 0.00037
-
-
 Homo sapiens Cilostamide
3.1.4.17 0.007
-
-
 Homo sapiens Milrinone
3.1.4.17 0.0127
-
-
 Homo sapiens IBMX
3.1.4.53 0.000021
-
-
 Homo sapiens rolipram
3.1.4.53 0.000042
-
-
 Homo sapiens Ro20-1724
3.1.4.53 0.0059
-
-
 Homo sapiens 3-isobuytl-1-methylxanthine