Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Conover, G.M.; Martinez-Morales, F.; Heidtman, M.I.; Luo, Z.Q.; Tang, M.; Chen, C.; Geiger, O.; Isberg, R.R.
    Phosphatidylcholine synthesis is required for optimal function of Legionella pneumophila virulence determinants (2008), Cell. Microbiol., 10, 514-528.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.8.24 from plasmid pGC41 in pGC36 for functional complementation in bacterial mutants lacking endogenous PcsA Legionella pneumophila

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.8.24 CDP-diacylglycerol + choline Legionella pneumophila phosphatidylcholine synthesis important for functionality of Dot/Icm translocator (formation of replicative vacuole), binding to macrophages, sufficient level of flagellin protein (linked to bacterial cytotoxicity, cellular adhesion) CMP + phosphatidylcholine
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.24 Legionella pneumophila
-
Philadelphia-1 strain Lp02 derivatives
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.24 CDP-diacylglycerol + choline phosphatidylcholine synthesis important for functionality of Dot/Icm translocator (formation of replicative vacuole), binding to macrophages, sufficient level of flagellin protein (linked to bacterial cytotoxicity, cellular adhesion) Legionella pneumophila CMP + phosphatidylcholine
-
?
2.7.8.24 CDP-diacylglycerol + choline overexpression of PcsA complements low phosphatidylcholine levels in membrane of mutant strain lacking PcsA or lacking both PcsA and PmtA (phospholipid N-methyltransferase) Legionella pneumophila CMP + phosphatidylcholine lipid analysis by thin-layer chromatography ?

Synonyms

EC Number Synonyms Comment Organism
2.7.8.24 PcsA
-
Legionella pneumophila
2.7.8.24 PcsA lidK/pcsA gene product Legionella pneumophila
2.7.8.24 phosphatidylcholine synthase
-
Legionella pneumophila