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Literature summary extracted from

  • Grant, P.A.; Best, S.L.; Sanmugalingam, N.; Alessio, R.; Jama, A.M.; Toeroek, K.
    A two-state model for Ca2+/CaM-dependent protein kinase II (alphaCaMKII) in response to persistent Ca2+ stimulation in hippocampal neurons (2008), Cell Calcium, 44, 465-478.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.17 T286A mutant clustering behaviour is similar compared to the wild type enzyme Rattus norvegicus
2.7.11.17 T286D mutant mimics autophosphorylation at Thr286 Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.17 KN-93 membrane permeant inhibitor of alphaCaMKII binding to Ca2+/calmodulin Rattus norvegicus
2.7.11.17 additional information not affected by myristoyl-RRKEQKTGHAVRAIGRE Rattus norvegicus
2.7.11.17 myristoylated autocamtide-2-related inhibitory peptide
-
 Rattus norvegicus
2.7.11.17 myristoylated Trp peptide 0.0135 mM prevents alphaCaMKII clustering Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.17 Ca2+ dependent on Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.17 Rattus norvegicus P11275
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.17 hippocampus
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.17 additional information Thr286-autophosphorylation is antagonistic to CaMKII clustering Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.17 alphaCa2+/CaM-dependent protein kinase II
-
 Rattus norvegicus
2.7.11.17 alphaCaMKII
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.17 ATP
-
 Rattus norvegicus
2.7.11.17 Calmodulin dependent on Rattus norvegicus