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Literature summary extracted from

  • Welsh, M.M.; Karagas, M.R.; Applebaum, K.M.; Spencer, S.K.; Perry, A.E.; Nelson, H.H.
    A role for ultraviolet radiation immunosuppression in non-melanoma skin cancer as evidenced by gene-environment interactions (2008), Carcinogenesis, 29, 1950-1954.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.3.1.3 estrogen transcriptional activator of histidase expression Homo sapiens
4.3.1.3 glucocorticoid transcriptional activator of histidase expression Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.3.1.3 L-histidine Homo sapiens enzyme catalyzes the formation of urocanic acid in the skin, modifies risk of basal cell carcinoma and squamous cell carcinoma trans-urocanic acid + NH3 urocanic acid is a UV radiation-absorbing molecule in the stratum corneum ?

Organism

EC Number Organism UniProt Comment Textmining
4.3.1.3 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.3.1.3 lymphocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.3.1.3 L-histidine enzyme catalyzes the formation of urocanic acid in the skin, modifies risk of basal cell carcinoma and squamous cell carcinoma Homo sapiens trans-urocanic acid + NH3 urocanic acid is a UV radiation-absorbing molecule in the stratum corneum ?

Synonyms

EC Number Synonyms Comment Organism
4.3.1.3 HAL
-
 Homo sapiens
4.3.1.3 histidase
-
 Homo sapiens
4.3.1.3 histidine ammonia-lyase
-
 Homo sapiens