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Literature summary extracted from

  • Barret, J.M.; Kruczynski, A.; Vispe, S.; Annereau, J.P.; Brel, V.; Guminski, Y.; Delcros, J.G.; Lansiaux, A.; Guilbaud, N.; Imbert, T.; Bailly, C.
    F14512, a potent antitumor agent targeting topoisomerase II vectored into cancer cells via the polyamine transport system (2008), Cancer Res., 68, 9845-9853.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.6.2.2 etoposide
-
 Cricetulus griseus
5.6.2.2 F14512 potent inhibitor, decreased sensitivity of L-1210 cells to F14512 in the presence of putrescine, spermidine, and spermine Cricetulus griseus

Organism

EC Number Organism UniProt Comment Textmining
5.6.2.2 Cricetulus griseus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.6.2.2 CHO cell
-
 Cricetulus griseus
-
5.6.2.2 CHO-K1 cell
-
 Cricetulus griseus
-
5.6.2.2 CHO-MG cell
-
 Cricetulus griseus
-
5.6.2.2 CHO-XRS6 cell
-
 Cricetulus griseus
-
5.6.2.2 L-1210 cell
-
 Cricetulus griseus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.6.2.2 supercoiled DNA + ATP + H2O
-
 Cricetulus griseus catenated DNA networks + ADP + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.6.2.2 Topoisomerase II
-
 Cricetulus griseus

Cofactor

EC Number Cofactor Comment Organism Structure
5.6.2.2 ATP
-
 Cricetulus griseus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
5.6.2.2 0.00000026
-
 in CHO-XRS6 cells Cricetulus griseus F14512
5.6.2.2 0.0000109
-
 in CHO-K1 cells Cricetulus griseus F14512
5.6.2.2 0.00012
-
 in CHO cells Cricetulus griseus F14512
5.6.2.2 0.000194
-
 in CHO-K1 cells Cricetulus griseus etoposide
5.6.2.2 0.000418
-
 in CHO-XRS6 cells Cricetulus griseus etoposide
5.6.2.2 0.0087
-
 in CHO-MG cells Cricetulus griseus F14512