Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Wilson, T.J.; Nannuru, K.C.; Futakuchi, M.; Sadanandam, A.; Singh, R.K.
    Cathepsin G enhances mammary tumor-induced osteolysis by generating soluble receptor activator of nuclear factor-kappaB ligand (2008), Cancer Res., 68, 5803-5811.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.21.20 medicine cathepsin G is a potentially novel therapeutic target in the treatment of breast cancer bone metastasis Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.20 Na-tosyl-Phe-chloromethylketone effectively inhibited the action of cathepsin G against the substrate at a concentration of 1 mmol/l Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.20 additional information Mus musculus enzyme enhances mammary tumor-induced osteolysis by generating soluble receptor activator of nuclear factor-KB ligand. It is significantly up-regulated at the tumor-bone interface and is capable of generating sRANKL, which potentially enhances osteoclast activation and osteolysis ?
-
 ?
3.4.21.20 additional information Mus musculus BALB/c enzyme enhances mammary tumor-induced osteolysis by generating soluble receptor activator of nuclear factor-KB ligand. It is significantly up-regulated at the tumor-bone interface and is capable of generating sRANKL, which potentially enhances osteoclast activation and osteolysis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.20 Mus musculus
-
 Balb/c mice
-
3.4.21.20 Mus musculus BALB/c
-
 Balb/c mice
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.20 4T1 cell murine breast adenocarcinoma cell line Mus musculus
-
3.4.21.20 Cl-66 cell murine breast adenocarcinoma cell line Mus musculus
-
3.4.21.20 Cl-66M2 cell murine breast adenocarcinoma cell line Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.20 additional information enzyme enhances mammary tumor-induced osteolysis by generating soluble receptor activator of nuclear factor-KB ligand. It is significantly up-regulated at the tumor-bone interface and is capable of generating sRANKL, which potentially enhances osteoclast activation and osteolysis Mus musculus ?
-
 ?
3.4.21.20 additional information enzyme enhances mammary tumor-induced osteolysis by generating soluble receptor activator of nuclear factor-KB ligand. It is significantly up-regulated at the tumor-bone interface and is capable of generating sRANKL, which potentially enhances osteoclast activation and osteolysis Mus musculus BALB/c ?
-
 ?
3.4.21.20 N-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
-
 Mus musculus N-succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
-
 ?
3.4.21.20 N-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
-
 Mus musculus BALB/c N-succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.20 cathepsin G
-
 Mus musculus