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Literature summary extracted from

  • Si, J.; Collins, S.J.
    Activated Ca2+/calmodulin-dependent protein kinase IIgamma is a critical regulator of myeloid leukemia cell proliferation (2008), Cancer Res., 68, 3733-3742.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.17 expressed in the LXSN retroviral expression vector M28248 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.17 imatinib downregulates CaMKIIgamma autophosphorylation/activation Homo sapiens
2.7.11.17 KN-62
-
 Homo sapiens
2.7.11.17 KN-93 inhibits CaMKII activity by blocking its interaction with the Ca2+/calmodulin complex Homo sapiens
2.7.11.17 additional information not inhibited by AG490, JAK3 inhibitor, PP1, PD98059, U0126, SB203580, wortmannin, LY294002, c-Jun NH2-terminal kinase inhibitor II, Raf 1 inhibitor, pho kinase inhibitor, RO-31-8220, Go6983, cucurbitacin I, Gleevec, and AMPK inhibitor Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.17 Ca2+ dependent on Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.17 Homo sapiens Q13555
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.17 acute myeloid leukemia cell
-
 Homo sapiens
-
2.7.11.17 chronic myeloid leukemia cell
-
 Homo sapiens
-
2.7.11.17 DAUDI cell
-
 Homo sapiens
-
2.7.11.17 DHL-4 cell
-
 Homo sapiens
-
2.7.11.17 HL-60 cell
-
 Homo sapiens
-
2.7.11.17 JURKAT cell
-
 Homo sapiens
-
2.7.11.17 K-562 cell
-
 Homo sapiens
-
2.7.11.17 Kasumi-1 cell
-
 Homo sapiens
-
2.7.11.17 KCL-22 cell
-
 Homo sapiens
-
2.7.11.17 KG-1 cell
-
 Homo sapiens
-
2.7.11.17 myeloid leukemia cell
-
 Homo sapiens
-
2.7.11.17 NB-4 cell
-
 Homo sapiens
-
2.7.11.17 RAJI cell
-
 Homo sapiens
-
2.7.11.17 Ramos cell
-
 Homo sapiens
-
2.7.11.17 THP-1 cell
-
 Homo sapiens
-
2.7.11.17 U-937 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.17 ATP + STAT3
-
 Homo sapiens ADP + phosphorylated STAT3
-
 ?
2.7.11.17 additional information CaMKIIgamma is activated by autophosphorylation Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.17 Ca2+/calmodulin-dependent protein kinase IIgamma
-
 Homo sapiens
2.7.11.17 CaMKIIgamma
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.17 ATP
-
 Homo sapiens
2.7.11.17 Calmodulin dependent on Homo sapiens