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Literature summary extracted from

  • Chen, X.; Zhong, S.; Zhu, X.; Dziegielewska, B.; Ellenberger, T.; Wilson, G.M.; MacKerell, A.D.; Tomkinson, A.E.
    Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair (2008), Cancer Res., 68, 3169-3177.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.5.1.1 2-[(3,5-dibromo-4-methylphenyl)amino]-N'-[(1E)-(2-hydroxy-5-nitrophenyl)methylidene]acetohydrazide
-
 Homo sapiens
6.5.1.1 4-chloro-5-[(2E)-2-[(4-hydroxy-3-nitrophenyl)methylidene]hydrazino]pyridazin-3(2H)-one
-
 Homo sapiens
6.5.1.1 6-amino-5-[[(1E)-phenylmethylidene]amino]-2-sulfanylpyrimidin-4-ol
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
6.5.1.1 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.5.1.1 HCT-116 cell
-
 Homo sapiens
-
6.5.1.1 HeLa cell
-
 Homo sapiens
-
6.5.1.1 MCF-10A cell
-
 Homo sapiens
-
6.5.1.1 MCF-7 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.5.1.1 ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m
-
 Homo sapiens AMP + diphosphate + (deoxyribonucleotide)m+n
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.5.1.1 DNA ligase I
-
 Homo sapiens
6.5.1.1 LigI
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
6.5.1.1 ATP
-
 Homo sapiens