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Literature summary extracted from
- The cyclin-dependent kinase inhibitor flavopiridol potentiates the effects of topoisomerase I poisons by suppressing Rad51 expression in a p53-dependent manner (2008), Cancer Res., 68, 2312-2320.
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 5.6.2.1 | additional information | p53-/- cell, p53-null variant of HCT116 cells | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.6.2.1 | CPT-11 | - |
Homo sapiens |  |
| 5.6.2.1 | flavopiridol | - |
Homo sapiens | |
| 5.6.2.1 | SN-38 | active metabolite of CPT-11 | Homo sapiens | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.6.2.1 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 5.6.2.1 | HCT-116 cell | wild-type and knocked out at p53 | Homo sapiens | - |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 5.6.2.1 | Topo I | - |
Homo sapiens |
| 5.6.2.1 | Topoisomerase I | - |
Homo sapiens |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.6.2.1 | cyclin | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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