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Literature summary extracted from

  • Korashy, H.M.; Brocks, D.R.; El-Kadi, A.O.
    Induction of the NAD(P)H:quinone oxidoreductase 1 by ketoconazole and itraconazole: a mechanism of cancer chemoprotection (2007), Cancer Lett., 258, 135-143.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.6.5.2 actinomycin D treatment of the cells with actinomycin D alone for 6 h significantly inhibits the constitutive NQO1 mRNA level by approximately 80%. KTZ- and ITZ-mediated Nqo1 induction is completely inhibited Mus musculus
1.6.5.2 itraconazole induces NQO1 mRNA and enzymatic activity levels in a concentration- and time-dependent manner in wild-type but not aryl hydrocarbon receptor-deficient Hepa-1c1c7 cells. Increases NQO1 de novo RNA synthesis without significantly affecting the levels of existing RNA. 50 micromol shows maximum NQO1 mRNA induction Mus musculus
1.6.5.2 ketoconazole induces NQO1 mRNA and enzymatic activity levels in a concentration- and time-dependent manner in wild-type but not aryl hydrocarbon receptor-deficient Hepa-1c1c7 cells. Increases NQO1 de novo RNA synthesis without significantly affecting the levels of existing RNA. 25 micromol shows maximum NQO1 mRNA induction Mus musculus
1.6.5.2 additional information fluconazole does not induce NQO1 Mus musculus
1.6.5.2 sulforaphane at a concentration of 5 micromol significantly induces NQO1 mRNA in both wild-type and C12 cells Mus musculus

Application

EC Number Application Comment Organism
1.6.5.2 drug development ability of ketoconazole and itraconazole to induce NQO1 gene expression at the transcriptional level through an aryl hydrocarbon receptor-dependent mechanism Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
1.6.5.2 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.6.5.2 Hepa-1c1c7 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.6.5.2 NAD(P)H + H+ + oxidized 2,6-dichlorophenolindophenol
-
 Mus musculus NAD(P)+ + reduced 2,6-dichlorophenolindophenol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.6.5.2 DT-diaphorase
-
 Mus musculus
1.6.5.2 NAD(P)H:quinone oxidoreductase 1
-
 Mus musculus
1.6.5.2 NQO1
-
 Mus musculus