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Literature summary extracted from

  • Slotkin, T.A.; Ryde, I.T.; Mackillop, E.A.; Bodwell, B.E.; Seidler, F.J.
    Adolescent nicotine administration changes the responses to nicotine given subsequently in adulthood: adenylyl cyclase cell signaling in brain regions during nicotine administration and withdrawal, and lasting effects (2008), Brain Res. Bull., 76, 522-530.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.6.1.1 forskolin forskolin activation is elevated by nicotine treatment in adolescence, especially in males Rattus norvegicus
4.6.1.1 Nicotine nicotine treatment in adulthood produces an immediate increase in adenylate cyclase activity in males that disappears upon withdrawal, nicotine increases the activating effect of forskolin, especially in males, overview Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.6.1.1 membrane
-
 Rattus norvegicus 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.6.1.1 Mg2+ activates Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.6.1.1 ATP Rattus norvegicus the adenylyl cyclase signaling cascade is involved in nicotine dependence and withdrawal, but also mediates numerous other neurotransmitter responses, effects of nicotine on adenylate cyclase enzyme activity: adolescent nicotine exposure elicits persistent suppression of basal adenylate cyclase activity and eventual compromise of responses to beta-adrenergic receptor stimulation, with effects emerging in late adulthood, overview 3',5'-cyclic-AMP + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.1 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.6.1.1 brain
-
 Rattus norvegicus
-
4.6.1.1 brain stem
-
 Rattus norvegicus
-
4.6.1.1 cerebellum
-
 Rattus norvegicus
-
4.6.1.1 cerebral cortex
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.6.1.1 additional information
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.6.1.1 ATP
-
 Rattus norvegicus 3',5'-cyclic-AMP + diphosphate
-
 ?
4.6.1.1 ATP the adenylyl cyclase signaling cascade is involved in nicotine dependence and withdrawal, but also mediates numerous other neurotransmitter responses, effects of nicotine on adenylate cyclase enzyme activity: adolescent nicotine exposure elicits persistent suppression of basal adenylate cyclase activity and eventual compromise of responses to beta-adrenergic receptor stimulation, with effects emerging in late adulthood, overview Rattus norvegicus 3',5'-cyclic-AMP + diphosphate
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
4.6.1.1 30
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.6.1.1 7.4
-
 assay at Rattus norvegicus