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Literature summary extracted from

  • Rumjahn, S.M.; Javed, M.A.; Wong, N.; Law, W.E.; Buxton, I.L.
    Purinergic regulation of angiogenesis by human breast carcinoma-secreted nucleoside diphosphate kinase (2007), Br. J. Cancer, 97, 1372-1380.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.4.6 ellagic acid inhibits NDPK and suppresses MDA-MB-435S cell growth Homo sapiens
2.7.4.6 epigallocatechin gallate EGCG, inhibits NDPK and suppresses MDA-MB-435S cell growth Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.4.6 extracellular the enzyme is secreted Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.4.6 ATP + NDP Homo sapiens
-
 ADP + NTP
-
 ?
2.7.4.6 additional information Homo sapiens MDA-MB-435S cell-secreted NDPK-B supports tumour formation by modulating ATP levels locally to activate endothelial cell P2Y receptor-mediated angiogenesis, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.4.6 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.4.6 breast carcinoma cell
-
 Homo sapiens
-
2.7.4.6 MDA-MB-435S cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.4.6 ATP + NDP
-
 Homo sapiens ADP + NTP
-
 ?
2.7.4.6 additional information MDA-MB-435S cell-secreted NDPK-B supports tumour formation by modulating ATP levels locally to activate endothelial cell P2Y receptor-mediated angiogenesis, overview Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.4.6 NDPK
-
 Homo sapiens
2.7.4.6 nucleoside diphosphate kinase
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.4.6 0.002 0.003
-
 Homo sapiens ellagic acid
2.7.4.6 0.008 0.01
-
 Homo sapiens epigallocatechin gallate