EC Number | Application | Comment | Organism |
---|---|---|---|
2.4.1.221 | molecular biology | O-fucosylation is dispensable for many Notch signaling events during Drosophila development | Drosophila melanogaster |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
2.4.1.221 | R254A | expression of a mutant, Ofut1R245A, lacking fucosyltransferase activity, rescues the requirement for Ofut1 in embryonic neurogenesis. Lack of requirement for O-fucosylation is further supported by the absence of embryonic phenotypes in Gmd mutants, which lack all forms of fucosylation. Requirements for O-fucose during imaginal development are evaluated by characterizing clones of cells expressing only Ofut1R245A. These clones phenocopy fringe mutant clones, indicating that the absence of O-fucose is functionally equivalent to the absence of elongated O-fucose | Drosophila melanogaster |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.1.222 | additional information | Drosophila melanogaster | transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.4.1.221 | Drosophila melanogaster | - |
- |
- |
2.4.1.222 | Drosophila melanogaster | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.4.1.222 | wing | - |
Drosophila melanogaster | - |
2.4.1.222 | wing disc | - |
Drosophila melanogaster | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.1.222 | additional information | transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor | Drosophila melanogaster | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.4.1.221 | O-fucosyltransferase 1 | - |
Drosophila melanogaster |
2.4.1.221 | OFUTI | - |
Drosophila melanogaster |
2.4.1.222 | FNG | - |
Drosophila melanogaster |
2.4.1.222 | N-acetylglucosaminyltransferase | - |
Drosophila melanogaster |