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Literature summary extracted from

  • Deng, X.; Gao, F.; May, W.S.
    Protein phosphatase 2A inactivates Bcl2s antiapoptotic function by dephosphorylation and up-regulation of Bcl2-p53 binding (2009), Blood, 113, 422-428.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.3.16 C2-ceramide potent PP2A activator Homo sapiens

Application

EC Number Application Comment Organism
3.1.3.16 medicine activating PP2A to dephosphorylate Bcl2 and/or increase Bcl2/p53 binding may represent an efficient and novel approach for treatment of hematologic malignancies Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.16 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.16 phosphorylated Bcl2 + H2O PP2A-mediated dephosphorylation of Bcl2 promotes its direct interaction with p53 as well as a conformational change in Bcl2, PP2A directly interacts with the BH4 domain of Bcl2 as a docking site to potentially bridge PP2A to Bcl2's flexible loop domain containing the target serine 70 phosphorylation site Homo sapiens Bcl2 + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.16 PP2A
-
 Homo sapiens
3.1.3.16 protein phosphatase 2A
-
 Homo sapiens