Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Kumada, H.; Mitsutake, S.; Inagaki, Y.; Mitsunaga, S.; Tsuchikawa, H.; Katsumura, S.; Igarashi, Y.
    Kinetics of the ceramide kinase inhibitor K1, a suppressor of mast-cell activation (2007), Biosci. Biotechnol. Biochem., 71, 2581-2584.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.7.1.138 medicine potential target for anti-allergic therapeutics Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.138 (4aR,6aS,12aS,12bR)-10-hydroxy-4,4,6a,12b-tetramethyl-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H-benzo(a)xanthene-8,11-dione KD, enantiomer of K1, strongly inhibits CerK activity Rattus norvegicus
2.7.1.138 (4aS,6aR,12aR,12bS)-10-hydroxy-4,4,6a,12b-tetramethyl-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H-benzo(a)xanthene-8,11-dione K1, non-competitive, suppresses the activation of mast cells, strongly inhibits CerK activity Rattus norvegicus
2.7.1.138 2,5-dihydroxy-3-(((1R,4aR,8aR)-5,5,8a-trimethyl-2-methylidenedecahydronaphthalen-1-yl)methyl)cyclohexa-2,5-diene-1,4-dione KB, enantiomer of K1, strongly inhibits CerK activity Rattus norvegicus
2.7.1.138 2,5-dihydroxy-3-(((1S,2S,4aS,8aR)-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl)methyl)cyclohexa-2,5-diene-1,4-dione KC, F12509A with an additional hydrogen at the double bond in methylene position, weak inhibition Rattus norvegicus
2.7.1.138 2,5-dihydroxy-3-(((1S,4aS,8aS)-5,5,8a-trimethyl-2-methylidenedecahydronaphthalen-1-yl)methyl)cyclohexa-2,5-diene-1,4-dione F12509A, inhibitor of sphingosine kinase 1, weak inhibition Rattus norvegicus
2.7.1.138 3-(cyclohexylmethyl)-2,5-dihydroxycyclohexa-2,5-diene-1,4-dione K2, cyclohexane derivative with a benzoquinone, weak inhibition Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.138 ceramide + ATP Rattus norvegicus CerK is involved in the regulation of mast cells ceramide 1-phosphate + ADP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.138 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.138 mast cell
-
 Rattus norvegicus
-
2.7.1.138 RBL-2H3 cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.138 ceramide + ATP
-
 Rattus norvegicus ceramide 1-phosphate + ADP
-
 ?
2.7.1.138 ceramide + ATP CerK is involved in the regulation of mast cells Rattus norvegicus ceramide 1-phosphate + ADP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.138 CERK
-
 Rattus norvegicus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.1.138 0.0022
-
 (4aS,6aR,12aR,12bS)-10-hydroxy-4,4,6a,12b-tetramethyl-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H-benzo(a)xanthene-8,11-dione
-
 Rattus norvegicus
2.7.1.138 0.0033
-
 (4aR,6aS,12aS,12bR)-10-hydroxy-4,4,6a,12b-tetramethyl-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H-benzo(a)xanthene-8,11-dione
-
 Rattus norvegicus
2.7.1.138 0.452
-
 2,5-dihydroxy-3-(((1S,2S,4aS,8aR)-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl)methyl)cyclohexa-2,5-diene-1,4-dione
-
 Rattus norvegicus