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Literature summary extracted from

  • Chebotareva, N.A.; Meremyanin, A.V.; Makeeva, V.F.; Livanova, N.B.; Kurganov, B.I.
    Cooperative self-association of phosphorylase kinase from rabbit skeletal muscle (2008), Biophys. Chem., 133, 45-53.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.19 additional information trimethylamin N-oxide induces association Oryctolagus cuniculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.19 EGTA addition of EGTA reverses Ca2+ induced association Oryctolagus cuniculus
2.7.11.19 NaCl 100 mM NaCl suppresses effect of Ca2+ and Mg2+ Oryctolagus cuniculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.19 Ca2+ induces association, obligatory allosteric activator, binds to an integral, nondissociable molecule of calmodulin (delta-subunit), and thus reveals the protein kinase activity of the catalytic gamma-subunit, which in the absence of Ca2+ ions is constrained by the regulatory alpha- and beta-subunits Oryctolagus cuniculus
2.7.11.19 Mg2+ induces association Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.19 glycogen phosphorylase b + ATP Oryctolagus cuniculus catalyzes phosphorylation and activation of glycogen phosphorylase b and hence plays a key role in the cascade system of regulation of glycogen metabolism glycogen phosphorylase a + ADP
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.19 Oryctolagus cuniculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.11.19
-
 Oryctolagus cuniculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.19 skeletal muscle
-
 Oryctolagus cuniculus
-

Storage Stability

EC Number Storage Stability Organism
2.7.11.19 20 °C, 25 mM Na-glycerol phosphate buffer, pH 7.05, 1 mM EDTA, 0.5 mM 2-mercaptoetanol, 50% glycerol, stored for 3 weeks Oryctolagus cuniculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.19 glycogen phosphorylase b + ATP catalyzes phosphorylation and activation of glycogen phosphorylase b and hence plays a key role in the cascade system of regulation of glycogen metabolism Oryctolagus cuniculus glycogen phosphorylase a + ADP
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.11.19 hexadecamer 4 * alpha + 4 * beta + 4 * gamma + 4 * delta Oryctolagus cuniculus

Synonyms

EC Number Synonyms Comment Organism
2.7.11.19 EC 2.7.1.38 formerly, transferred to EC 2.7.11.19 Oryctolagus cuniculus
2.7.11.19 PhK
-
 Oryctolagus cuniculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.19 additional information capable of binding FAD, binding of FAD suppresses self association of enzyme Oryctolagus cuniculus